Questions? Call us at 800-810-7790
May 23, 2024

Blood Pressure


Spironolactone (Aldactone)

What is it?

Spironolactone is used for managing high blood pressure and edema (fluid build up) typically caused by liver disease, kidney disease, and other conditions.

Spironolactone is in the drug class “diuretics,” commonly known as “water pills.” The medication increases urine production and flushes out excess water and salt.

The drug is also offered as a topical solution. Spironolactone cream is used to treat acne, specifically hormonal acne in adults as it reduces the amount of aldosterone produced.

Spironolactone Dosage

Your spironolactone prescription can range anywhere from 25 mg to 100 mg per day depending on your condition and responsiveness to the medication.

Your healthcare provider may adjust your prescription based on your responsiveness to the medication.

Pediatric use is not recommended as studies of safety and efficacy in children are limited.

Spironolactone Side Effects

Common Side Effects

These side effects are mild and usually short-lived as the body adjusts to the medication. If any of the following side effects become bothersome or last more than a few days speak to your pharmacist or healthcare provider:

  • Dizziness
  • Nausea
  • Muscle cramps
  • Fatigue
  • Breast pain/enlargement in women
  • Gynecomastia in men
Serious Side Effects

These side effects are rare but could indicate serious health complications. Speak to your healthcare provider immediately if you experience any of the following:

  • Yellowing of skin/eyes
  • Slow/irregular heartbeats, tingling, muscle weakness, and shortness of breath
  • Decrease in urination, strong smelling/dark urine, and feeling of drowsiness or nausea
  • Allergic reaction (e.g., itching/rash, difficulty breathing, swelling in face/throat, etc.)
Spironolactone and Pregnancy

It is not recommended to use spironolactone while pregnant as there is a possibility of risk to male fetuses due to anti-androgenic properties of spironolactone. If you are taking spironolactone and plan on becoming pregnant, speak to your healthcare provider about alternate treatments.


Some medications are known to affect the way spironolactone works or increase your chance of side effects. Speak to your healthcare provider about any current medications and new medications you may begin taking while on spironolactone.

Some medications that may interact with spironolactone are:

  • Other medications used to treat high blood pressure or have the side effect of lowering blood pressure
  • Medications that effect potassium
  • Digoxin
  • NSAIDs (e.g., ibuprofen, naproxen)
Spironolactone and Alcohol

Alcohol is also a diuretic which can increase your risk of dehydration and other adverse effects when mixed with spironolactone. Alcohol also affects your blood pressure and heavy drinking can lead to heightened blood pressure.

If you choose to drink, be sure to not exceed the daily recommended limit of 1 unit/day for women and 2 units/day for men.

Spironolactone Cost

The average retail spironolactone price is $16.21/month for 25 mg tablets.

Spironolactone: Where to Buy?

Marley Drug offers affordable spironolactone online through our Wholesale Price List.

Get spironolactone and over a hundred other medications for as little as $5.83/month with no insurance required plus free shipping to all 50 states.

Questions? Call us at 1 800-810-7790 and our pharmacy team will be happy to help.

Related posts

3 Myths Debunked on Heart Disease

How to Lower High Blood Pressure (Hypertension): What Blood Pressure is Normal?

Calcium Channel Blockers and High Blood Pressure