Yaz vs Slynd - How to Choose the Right Birth Control for You

Updated May, 2025.

How Do Hormonal Birth Control Pills Work?

Birth control pills prevent pregnancy by targeting specific phases of the menstrual cycle. They achieve this by introducing synthetic hormones into the body to maintain a consistent hormone level, thus preventing the hormonal fluctuations responsible for the cycle. The primary hormones used in birth control pills are synthetic estrogens and progesterone (progestin).

Progestin plays a significant role in birth control by thickening the cervical mucus, which hinders the movement of sperm into the uterus. It also prevents the hormonal changes that trigger ovulation, effectively blocking the release of eggs. While estrogen also contributes to preventing ovulation, its primary function is often considered to be maintaining a "normal" menstrual cycle.

Read about Types of Birth Control

How to Choose the Right Birth Control Pill

Choosing a birth control pill can be challenging due to the wide range of options available. Not only are there different types of pills, such as monophasic, biphasic, and progestin-only pills, but there are also numerous choices within each category. Two commonly compared pills are Yaz, a monophasic pill, and Slynd, a progestin-only pill. So, when faced with the decision of selecting a birth control pill, which one should you choose?

Yaz vs Slynd

Yaz and Slynd are both highly effective birth control pills with different hormone contents.

Yaz

Yaz is a combination pill that contains two active ingredients, ethinyl estradiol and drospirenone. Ethinyl estradiol is a synthetic form of estrogen, while drospirenone is a progestin (synthetic progesterone).

These hormones work together to prevent pregnancy by:

• Stopping ovulation: Generally, once a month, your ovaries release an egg, which is called ovulation. If there’s no egg, sperm can’t fertilize anything. These hormones stop that egg from being released in the first place, so there’s nothing for sperm to meet.
• Thickening cervical mucus: The cervix is the opening to the uterus. Normally, the mucus there becomes thinner around ovulation so sperm can swim through it. But in this case, the mucus is thicker and stickier, which blocks sperm and makes it harder for them to travel up to the egg.
• Thinning the uterine lining: Each month, the body prepares for a possible pregnancy by building up the lining of the uterus, where a fertilized egg would attach and grow. In this case, the lining is thinner than usual. Therefore, if an egg did get fertilized (which is already unlikely due to the first two effects), it would be harder for it to attach and develop in a thin lining.

Slynd

Slynd is a progestin-only pill (POP) containing drospirenone. It helps prevent pregnancy mainly by stopping ovulation, which means it keeps your ovaries from releasing an egg. Without an egg, pregnancy can’t happen. It also changes the conditions inside your body to make it more difficult for sperm to travel and for a fertilized egg to stick to the uterus and grow.

Read more about Combination Pills vs Progestin-Only Pills

Administration

Both pills come in a 28-day pill package.

Yaz

Yaz is taken daily for 24 days, followed by a 4-day break where placebo pills are taken. Active pills contain 0.02 mg ethinyl estradiol and 3 mg of drospirenone.

Slynd

Slynd is packaged in a 28-day supply. It includes 24 white tablets, each containing 4 mg of drospirenone, and 4 green placebo tablets. You take 1 white tablet daily for the first 24 days, followed by 1 green tablet each day for the remaining 4 days of the pack.

Indications

While both medications are used for pregnancy prevention, Yaz has two additional FDA-approved indications:

• Treatment for premenstrual dysphoric disorder (PMDD): Yaz is approved to alleviate the symptoms of PMDD, a more severe form of premenstrual syndrome (PMS). It can help manage symptoms such as mood swings, bloating, and irritability.
• Treatment of moderate acne: Yaz is also approved for the treatment of moderate acne in women aged 14 years and older. It can be beneficial in reducing acne breakouts and improving the overall appearance of the skin.

Who Can Not Take These Medications

Both Yaz and Slynd are generally safe for most individuals, but there are some considerations and contraindications to be aware of. The differences between the two medications are primarily due to the presence of estrogen in Yaz.

Avoid both Yaz and Slynd if you:

• Are pregnant
• Have breast cancer
• Experience undiagnosed vaginal bleeding
• Have adrenal disorders
• Have active liver disease

Avoid Yaz specifically and consider using Slynd if you:

• Are within 6 weeks of delivery
• Smoke and are older than 35 years
• Have uncontrolled high blood pressure or diabetes
• Have a history of blood clot
• Experience migraines with aura

Side Effects

Both Yaz and Slynd, like any medications, may have potential side effects. Due to the differences in hormone types and strengths between the two pills, the specific side effects can vary slightly. Here are the most common side effects associated with each contraceptive pill, listed in descending order of likelihood:

Yaz

• Headache
• Changes in menstrual periods (spotting, irregular periods)
• Nausea
• Breast pain or tenderness
• Mood changes

Slynd

• Acne
• Abnormal menstrual bleeding (occurring outside of the expected "period" timeframe)
• Headache
• Breast pain or tenderness

Side effects of oral contraceptives are often worst during the initial three months of use. Beyond this period these symptoms generally improve significantly or may even resolve completely. Therefore, it is commonly recommended to continue using a specific contraceptive for at least three months before considering a switch due to side effects, unless the side effects are severe. This timeframe allows for the body to adjust to the medication, increasing the likelihood of symptom improvement over time.

Cost

Price is likely the biggest difference between these two medications. Many progestin-only birth control pills are costly, particularly those containing drospirenone rather than norethindrone. The average retail price of a single 28-day package of Slynd is $236. Price for Yaz averages aroundy $55 for the same 28-day supply. However, this may change based on your insurance and/or specific pharmacy.

Which One Should I Be On?

Yaz and Slynd are highly effective birth control pills. The choice depends on your own preferences, budget, and medical history. There are a number of things to consider, which are all outlined in this table.

Prices mentioned in this article are based on average retail price at major box chain pharmacy in the U.S. as of May 30, 2023.