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<h1><strong>Get Generic Brilinta (ticagrelor) Delivered</strong></h1><ul><li><strong>Available in 60mg and 90mg tablets</strong></li><li><strong>Free home delivery to all 50 states</strong></li><li><strong>FDA-approved medication—Prescription required</strong></li></ul>

WELCOME TO MARLEY DRUG

<h3><strong>Generic Brilinta Now Available at Marley Drug</strong></h3>
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<p>As of May 2025, a lower cost generic of Brilinta is available at Marley Drug. The generic version is FDA-approved and is considered the same in terms of quality, safety, and efficacy as the brand-name drug.</p>

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<h3><strong>About Brilinta (ticagrelor)</strong></h3>
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<p>Brilinta (ticagrelor) is a prescription medication used to prevent blood clots in patients who have experienced a heart attack or severe chest pain. </p>

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<p>Brilinta is an <a href="https://www.marleydrug.com/blog/antiplatelet-medications" rel="noopener noreferrer" target="_blank" style="font-variant-ligatures: inherit; font-variant-caps: inherit;">antiplatelet</a>. It works by preventing platelets in your blood from sticking together and forming clots. This helps reduce the risk of future heart attacks, strokes, and other serious cardiovascular events.</p>
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<p>Brilinta is typically prescribed alongside low-dose aspirin and is taken twice daily. It's important to follow your healthcare provider's instructions carefully to ensure the medication's effectiveness and to minimize potential side effects, such as bleeding.</p>

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<h5 style="font-weight:400; color:#ffffff; line-height:1.5;">On a recent survey, 99% of our customers answered they would recommend Marley Drug to a family member or friend.</h5>
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I really love Marley’s quick responses and the fact that I can purchase a 6 month supply rather than running to the drugstore every 30/90 days. The staff is wonderful, helpful and knowledgeable.  I love working with Terri Reid. I would recommend Marley to friends.

The Wholesale Price List made my prescription easy to afford,  I was about to cancel my prescription because my monthly cost with insurance was almost $150!  Now I can get a 6-month supply for only $37, which is much less money than a one month supply using my insurance. Thanks Dee for calling and letting me know my options!

Great Pharmacy. If your insurance company will not pay, you can get medications. A lot cheaper.

Check out this mail in pharmacy. My cardiologist referred me to them for best price on cholesterol lowering med. I found them to be helpful, professional and provide prompt service.

As soon as my doctor submitted the prescription, I was contacted by Terri, who explained the process and set up delivery to my home. It could not have been easier!

What Our Customers Have to Say

<p class="ql-align-center">Through our online portal you can provide us your medical history and prescription details. Questions? Call <a href="tel:800-810-7790" rel="noopener noreferrer">800-810-7790</a>.</p>

Provide us your prescription details

<p class="ql-align-center">Our pharmacy team will verify your prescription details.</p>

We'll verify your prescription

<p class="ql-align-center">All medications are shipped by First Class mail and will arrive in 2-3 business days.</p><p><br></p>

Your medication will be shipped to your home

How to Order Generic Brilinta (ticagrelor)

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<h2>Have medication questions for Generic Brilinta (ticagrelor)?<br>Talk with a pharmacist today.</h4>
<p>Call us for a free pharmacy consult.<br><br>
<a class="btn btn-brand" href="tel:800-810-7790" target="_blank" style="padding:10px 17px;" >800-810-7790</a></p>

Brilinta (ticagrelor) Commonly Asked Questions

<div style="border-left: 5px solid #fee203;  padding-left: 15px; padding-right: 15px; margin-bottom: 40px; margin-top: 40px; font-family: 'montserratlight', sans-serif; font-size: 1.2em; line-height: 160%;">

<p>Have you ever asked your pharmacist what the cash-price is for your medication?<br>
Probably not, but you should!<br>
Most of our patients are shocked when they learn how much they can save by paying cash for their medications, rather than using the traditional route of applying their insurance and paying what they felt was a ‘small copay’.</p>

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<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">What does it mean to pay cash for your prescriptions?</h3>

<p>Paying cash for your prescriptions means that you are paying for your medications <span style="font-family: 'montserrat', sans-serif;"> without using any insurance.</span>  The cost associated with this price includes the cost for the pharmacy to acquire the medication at a wholesaler, pharmacy dispensing fees, and an arbitrary mark-up for the pharmacy to make money. That mark-up is usually pharmacy dependent.</p>


<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">Why is the cash-price different than the insurance-price?</h3>

<p><strong>General Assumption</strong>: One would think using insurance should always be less than paying cash.<br>

In reality, the cash-price and insurance-price are two separate things.<br>

The <span style="font-family: 'montserrat', sans-serif;"> insurance price</span>, the price you pay for medications using your insurance at the pharmacy is decided by your insurance company and the <a href="https://www.marleydrug.com/blog/congressman-comer-investigates-pbms-and-rising-healthcare-costs-inside-view-from-a-pharmacy-and-drug-manufacturer">pharmacy benefit manger (PBM)</a> they hired to negotiate a “better price” for you.</p>

<div style="border-left: 5px solid #fee203;  padding-left: 15px; padding-right: 15px; margin-bottom: 40px; margin-top: 40px; font-family: 'montserratlight', sans-serif; font-size: 1.2em; line-height: 160%;"><strong>Did you know?</strong> The pharmacy has no say in the price when you use insurance.</div>

<p><span style="font-family: 'montserrat', sans-serif;">Reason for the price discrepancy: </span>While we as a pharmacy can purchase the medication for next to nothing, your insurance company and their PBM may have negotiated a different price and then marked it up a bit to make some money for their services.</p>

<p>We as a pharmacy have to offer that price to you based on what they negotiated and decided on, even if we can offer it to you for less!</p>

<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">Why haven’t I heard about this better offer?</h3>

<p><strong>Gag clauses </strong>have prevented pharmacists from telling you about a better deal.</p>

<p>You may not have heard that paying cash can often be cheaper that using insurance, and that’s likely because of <span style="font-family: 'montserrat', sans-serif; color:#333333;">unethical laws</span> that currently exist preventing pharmacists from telling you about a better deal.</p>

<p>There are gag clause contracts with pharmacies and PBMs that prevent pharmacists from telling patients about affordable alternatives.</p>

<p>Some good news though, on October 10, 2018, <span style="font-style: italic; font-weight: 600;">Bill S.2553, Know the Lower Price Act</span> was instated <span style="font-style: italic; font-weight: 600;">which allows pharmacists to inform patients under Medicare or Medicare Advantages plans of lower-price cash options</span>.</p>

<div style="margin: 30px 15px 30px 15px; background-color: #fee203; padding: 20px; font-family: 'montserratlight', sans-serif; line-height: 160%;">This bill prohibits a prescription drug plan under Medicare or Medicare Advantage from restricting a pharmacy from informing an enrollee of any difference between the price, co-payment, or co-insurance of a drug under the plan and a lower price of the drug without health-insurance coverage (such restrictions are commonly referred to as gag clauses).</div>

<p>While many laws still need to be changed to prevent these unethical practices, this new bill is a great step in the right direction to provide price transparency for patients.</p>



<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">How can it be more affordable to pay for prescriptions without insurance?</h3>

<p>Paying for your prescriptions with insurance can cost more because it requires more steps to get your medications through the <a style="color: #222222; text-decoration: none; border-bottom:.125em solid #5ba2b6;" href="#" target="_blank" rel="noopener">supply chain</a>.</p>


<div style="border-left: 5px solid #fee203; padding-left: 15px; padding-right: 15px; margin-bottom: 40px; margin-top: 40px; font-family: 'montserratlight', sans-serif; font-size: 1.2em; line-height: 160%;"><strong>Did you know?</strong> When you use your insurance, there is an extra player involved: the PBM middlemen, who are paid by your insurance company to negotiate better pricing with drug manufacturers.</div>

<img src="https://marley-storage.imgix.net/0092b4de-f216-453f-9522-6e2cef93c920/bl-cashprice-steps-3.png" alt="Cash price vs copay" width="100%" height="auto">
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<p>Built into these overcomplicated negotiations are administrative fees as well as unethical pricing strategies, termed <u><a href="https://www.marleydrug.com/blog/how-spread-pricing-increases-prices-of-generic-drugs">spread pricing</a></u>, which can profusely inflate the cost of medications.</p>

<div style="border-left: 5px solid #fee203;  padding-left: 15px; padding-right: 15px; margin-bottom: 40px; margin-top: 40px; font-family: 'montserratlight', sans-serif; font-size: 1.2em; line-height: 160%;">According to a recent analysis by Kaiser Health News, the price of medications when using health insurance can add costs of up to $30 per prescription.</div>

<p>These PBM and insurance company middlemen have been getting away with this unethical practice for decades and ultimately costing both employers and patients hundreds of millions more for the cost of generic medications.</p>

<p>In recent years, some states have introduced new laws to fight high drug prices and restrict practices that are costing taxpayers hundreds of millions every year.</p>

<p>Paying the cash price for your prescription means you can bypass the additional fees and middlemen which cause price inflation when you pay with insurance.</p>


<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">Don’t assume your insurance is saving you money</h3>

<p>$10 per month is the national average copay for generic medications.</p>

<p><strong>The Assumption: </strong>The assumption we all make is that our insurance copay is a good deal for us. With an average $10 copay, one would assume the medication costs a lot more than $10, especially since your insurance is also paying for some of it.</p>

<p><strong>The Reality: </strong>The reality is that most generic medications cost next to nothing for pharmacies to buy. That $10 copay you are paying is extremely inflated and you and your insurance provider are overpaying for your medications. In fact, using your insurance may be costing you more.</p>



<div style="border-left: 5px solid #fee203; padding-left: 15px; padding-right: 15px; margin-bottom: 40px; margin-top: 40px; font-family: 'montserratlight', sans-serif; font-size: 1.2em; line-height: 160%;">Millions of Americans skip doses or stop taking their prescription because of the cost&mdash;the medications you need should always be affordable</div>
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<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">Real Life Example&mdash;How paying with insurance costs you more</h3>

<p>Many of our customers are often shocked to learn that paying cash is often less expensive than using insurance.</p>



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<h4>Here’s a real-life example:</h4>

<p>Janice has a prescription for rosuvastatin (generic Crestor<sup>®</sup>) and wants to find the best savings for her medication. When Janice uses her insurance, she pays a copay of $10.00 a month. She assumes this is a good deal for her because the price she sees at the pharmacy, the price the PBM “negotiated” for her is $80 a month and Janice’s insurance covers $70 of the prescription giving her an 87.5% savings.</p>

<p>If Janice had asked for the cash price, she would be shocked to learn that her same rosuvastatin prescription is available at the cash price for less than her $10 copay.</p>

<p>At Marley Drug, Janice could get rosuvastatin (generic Crestor<sup>®</sup>) for $6.17 per month with a 6-month supply (38% less than a $10 copay) or $5.83 per month with a 12-month supply (41% less than a $10 copay.) That’s because it’s on a list of over 100 generic medications that we offer on <a style="color:#ffffff; text-decoration: none; border-bottom:0.125em solid #fee203; " href="https://www.marleydrug.com/wholesale-price-list" target="_blank" rel="noopener">Marley Drug's Wholesale Price List</a>. </strong></p>

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<p>An important point not to be overlooked; Janice’s insurance plan is also paying a lot of money for this medication&mdash;$70/month! That’s an additional $840/year of healthcare costs on top of the extra $50 Janice is paying compared to our price.</p>

<p>What may seem like a low copay that is beneficial for patients is actually riddled with hidden fees by unethical middlemen. This ultimately drives up the cost of healthcare and increases the costs you and/or your employer pay for your health plan.</p>

<p>Whether you have a high copay, or a <a style="color: #222222; text-decoration: none; border-bottom:.125em solid #5ba2b6;" href="https://www.marleydrug.com/never-going-to-pay-through-your-high-deductible-save-money-by-paying-cash-at-marley-drug/" target="_blank" rel="noopener">high deductible</a>, our savings programs at Marley Drug often save you money!</p>


<h3 style="font-size: 1.5em; font-family: 'montserratbold', sans-serif; color: #222222;">Save on your Prescriptions at Marley Drug by paying without insurance</h3>

<p>Marley Drug has over 100 generic prescriptions available through our <a style="color: #222222; text-decoration: none; border-bottom:.125em solid #5b2b6" href="https://www.marleydrug.com/wholesale-price-list" target="_blank" rel="noopener">Wholesale Price List</a> which means you can get your same generic prescriptions at an affordable price, including free shipping.

<ul style="list-style-type: disc; list-style-position: outside; padding-bottom: 15px;">
 	<li style="margin-bottom:5px;">$6.17 per month when you buy a 6-month supply&mdash;38% less than a $10 copay!</li>
 	<li style="margin-bottom:5px;">$5.83 per month when you buy a 12-month supply&mdash;41% less than a $10 copay!</li>
</ul>

<p>No added pharmacy fees&mdash;No copay&mdash;Free shipping right to your door<br>

Call Sam, Julie or Juan in our U.S. Support Center at 800-810-7790&mdash;they would love to speak with you!</p>

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Most of our patients are shocked when they learn how much they can save by paying cash for their medications, rather than using the traditional route of applying their insurance and paying what they felt was a ‘small copay’.

Don’t assume your insurance is saving you money. Learn how you can save money by avoiding insurance and paying cash. Shop online today at Marley Drug.

How to Save Money on Medications by Paying Cash

Cash price might be lower than your copay

Understanding Drug Pricing

How Paying Cash for Your Prescriptions Can Cost Less Than Your Copay

<p>Cholesterol has been a subject of debate in cardiovascular health. Despite its crucial role in various bodily functions, questions persist about its association with atherosclerotic cardiovascular disease (ASCVD). </p>
	
		
	<h3>What is cholesterol?</h3>
	
	
	<p>Cholesterol is a waxy, fat-like substance found in every cell of the body, essential for producing hormones, vitamin D, and substances that help digest foods. It is transported through the bloodstream by lipoproteins, which are composed of fat on the inside and proteins on the outside. There are two primary types of lipoproteins: </p>
	
	<ul>
		<li style="line-height:1.6; margin-bottom:30px;"><strong>Low-density lipoprotein (LDL): </strong>Often referred to as "bad" cholesterol, carries cholesterol from the liver to the cells. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries, forming plaques that can narrow or block blood flow, leading to atherosclerosis and increasing the risk of heart disease and stroke. </li>	
		
		<li style="line-height:1.6; margin-bottom:30px;"><strong>High-density lipoprotein (HDL): </strong>Known as "good" cholesterol, helps remove excess cholesterol from the bloodstream, transporting it back to the liver for processing and excretion. This balance between LDL and HDL is crucial for maintaining cardiovascular health.</li>
	</ul>
	
	<p>Understanding the basics of cholesterol is essential before we delve into common myths and misconceptions.</p>
	
	<h3>Debunking Common Cholesterol Myths</h3>
	
	<h5><strong>Myth #1: Cholesterol does not play a role in ASCVD</strong></h5>
	
	
	<p>The lipid/cholesterol hypothesis suggests that high levels of LDL cholesterol play a central role in the development of ASCVD. This is supported by a wide variety of clinical evidence accumulated for over a century. </p>
	
	<p>In 1913, Nikolaj Anitschkow set the groundwork for the lipid hypothesis<sup>[1]</sup>. Anitschkow's work involved feeding cholesterol to rabbits and then observing the effects of this diet on the arteries of the rabbits. Anitschkow found that the rabbits fed with cholesterol developed artery-clogging plaques, similar to those found in humans with heart disease. This discovery was the first evidence that linked dietary cholesterol to development of atherosclerosis, a primary underlying cause of heart disease. </p>
	
	<p>But it's not just about rabbits; the result of this study applies to humans too. Over the years, research in humans has confirmed what Anitschkow found: high cholesterol levels are linked to a higher risk of heart disease. </p>
	
	<p>The Framingham Heart Study<sup>[2]</sup> began in 1948 and is now on its third generation of participants. It has been pivotal in understanding cardiovascular risk factors. Using epidemiological and genetic techniques, this long-term study has demonstrated a clear association between elevated LDL levels and increased risk of heart disease. The study's comprehensive data collection and analysis have significantly influenced public health guidelines and cholesterol management strategies.</p>
	
	<p>Additionally, physiologist Ancel Keys’ epidemiological work<sup>[3]</sup> in the 1950s helped solidify the lipid hypothesis. He observed a correlation between dietary fat intake and blood cholesterol levels in populations around the world. He was able to determine that in societies where dietary fat was a major component of every meal, such as in the US, both blood cholesterol levels and heart disease death rates were highest. Conversely, in cultures with diets rich in fresh fruits and vegetables, bread, pasta, and olive oil, such as the Mediterranean region, blood cholesterol levels were low and heart disease was rare.</p>
	
	<p>Modern clinical data continues to support these early findings. The INTERHEART study<sup>[4]</sup> highlighted the significance of lipids in myocardial infarction risk across different populations globally. It demonstrated that abnormal lipid levels, particularly high LDL cholesterol, are one of the most important risk factors for heart attacks. </p>
	
	<p>In conclusion, the evidence overwhelmingly supports the role of cholesterol in the development of ASCVD. High levels of LDL cholesterol are a well-established risk factor, and managing these levels is essential for cardiovascular health.</p>
	
	
	
	<h5><strong>Myth #2: Cholesterol-lowering treatment does not lower the risk of ASCVD</strong></h5>
	
	<p>Clinical trials and extensive research have shown that lowering LDL cholesterol levels reduces the risk of ASCVD<sup>[5]</sup>. <a href="https://www.marleydrug.com/blog/what-are-statins">Statins</a>, a class of drugs that lower cholesterol levels, have been proven to significantly decrease the incidence of heart attacks and strokes by up to 20-30%<sup>[6]</sup>.</p>
		
	<p>The Scandinavian Simvastatin Survival Study (4S)<sup>[7]</sup> demonstrated that lowering LDL cholesterol with statin therapy significantly reduced the incidence of heart attacks and strokes in high-risk individuals. In this study, simvastatin reduced total cholesterol by 25% and LDL cholesterol by 35%, which resulted in a 34% reduction in major coronary events and a 30% reduction in all-cause mortality over five years. </p>
	
	<p>Similarly, the Heart Protection Study (HPS)<sup>[8]</sup> provided evidence supporting the benefits of cholesterol-lowering treatments in reducing cardiovascular events. The HPS, which involved over 20,000 participants, showed that simvastatin reduced the risk of heart attacks, strokes, and revascularization procedures by about 25% even in individuals with no prior history of heart disease, reinforcing the preventive benefit of statin therapy.</p>

	
	<h5><strong>Myth #3: High cholesterol levels are only a concern for older adults</strong></h5>
	
	<p>Elevated cholesterol levels pose a threat across all age groups, including younger individuals. <a href="https://www.marleydrug.com/blog/familial-hypercholesterolemia-fh">Familial hypercholesterolemia (FH)</a> is an inherited condition characterized by elevated LDL cholesterol levels, exemplifying how high cholesterol can afflict individuals from a young age and cause premature ASCVD. Furthermore, the onset of atherosclerosis in youth underscores the importance of addressing cholesterol levels from an early age to reduce the risk of cardiovascular complications. Lifestyle modifications, such as adopting a heart-healthy diet, and engaging in regular physical activity are important interventions for cholesterol management in both younger and older populations<sup>[9]</sup>.</p>
	
	
	<h5><strong>Myth #4: Only LDL cholesterol levels matter</strong></h5>
	
	<p>While LDL cholesterol is a significant factor in heart disease, it's not the only one that matters. HDL cholesterol, triglycerides, and other lipid particles also play important roles in cardiovascular health. The Framingham Heart Study<sup>[2]</sup> found that low levels of HDL cholesterol were associated with an increased risk of coronary heart disease, independent of LDL cholesterol levels. Additionally, elevated triglyceride levels have been linked to a higher risk of cardiovascular events, as shown in the Copenhagen City Heart Study<sup> [10]</sup>. A comprehensive approach to lipid management, including lowering LDL, raising HDL, and managing triglycerides, is crucial for reducing overall cardiovascular risk.</p>
	
	
	<h5><strong>Myth #5: If high LDL-C is the major cause of ASCVD, then people with the highest LDL-C values would have shorter lives than people with lower values</strong></h5>
	
	<p>Ravnskov et al.,<sup>[11]</sup> looked at 19 existing studies which considered the association between LDL-C levels and the overall risk of death in people aged over 60. The authors reported a statistically significant inverse association between all-cause death and LDL-C levels and concluded that their findings question the validity of the prevailing cholesterol hypothesis and provide rationale for a re-evaluation of guidelines that recommend reducing LDL-C levels in the elderly as a component of cardiovascular disease prevention. </p>
	
	<p>However, this interpretation has been met with significant criticism. Critics argue that the inverse association observed by Ravnskov could be due to several factors, including reverse causation, where individuals with serious illnesses often have lower cholesterol levels due to their condition or treatments. Additionally, frailty and malnutrition in the elderly can lead to lower cholesterol levels, complicating the direct relationship between LDL-C and mortality<sup>[12]</sup>. </p>
	
	<p>In contrast, extensive longitudinal studies, such as the Framingham Heart Study<sup>[2]</sup>, provide robust evidence supporting the role of high LDL-C in increasing ASCVD risk. Duncan et al.,<sup>[13]</sup> analyzed the Framingham cohort over 35 years and identified distinct LDL-C trajectory groups. Their findings showed that individuals with consistently elevated LDL cholesterol levels throughout life experienced significantly higher rates of ASCVD and all-cause mortality compared to those with optimal or declining LDL cholesterol levels.</p>
	
	
	
	<h3>Conclusion</h3>
	
	<p>Despite the abundance of evidence linking cholesterol to ASCVD, myths and misconceptions persist. Understanding the facts about cholesterol and its impact on cardiovascular health is crucial for making informed decisions about managing your health. By debunking these common myths, we can better appreciate the importance of cholesterol management in preventing heart disease and promoting overall well-being.</p>
	
	
	
	
	

	<div style="font-size:.85em; border-top:1px dotted #747474; margin-top:50px; padding-top:30px;">
		<p style="margin-bottom:10px;"><strong>References:</strong></p>
		
		<ol>
			<li>Anitschkow N. Über die Veränderungen der Kaninchenaorta bei experimenteller Cholesterinsteatose. Verhandlungen der Deutschen Pathologischen Gesellschaft. 1913;16:22-24.</li>
			<li>Framingham Heart Study. National Heart, Lung, and Blood Institute. Accessed June 17, 2024. Available at: https://www.framinghamheartstudy.org/</li>
			<li>Keys A. Atherosclerosis: a problem in newer public health. Journal of Mount Sinai Hospital, New York. 1953;20:118-139.</li>
			<li>Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., et al. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet, 364(9438), 937-952. https://doi.org/10.1016/S0140-6736(04)17018-9</li>
			<li>Baigent, C., et al. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. The Lancet, 376(9753), 1670-1681..</li>
			<li>Baigent, C., et al. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. The Lancet, 376(9753), 1670-1681.</li>
			<li>Scandinavian Simvastatin Survival Study Group. (1994). Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). The Lancet, 344(8934), 1383-1389. doi:10.1016/S0140-6736(94)90566-5.</li>
			<li>Heart Protection Study Collaborative Group. (2002). MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. The Lancet, 360(9326), 7-22. doi:10.1016/S0140-6736(02)09327-3.</li>
			<li>Centers for Disease Control and Prevention (CDC). (2023). Cholesterol. Retrieved from https://www.cdc.gov/cholesterol/.</li>
			<li>Nordestgaard, B. G., Benn, M., Schnohr, P., & Tybjærg-Hansen, A. (2007). Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA, 298(3), 299-308. doi:10.1001/jama.298.3.299.</li>
			
			<li>Ravnskov, U., Diamond, D. M., Hama, R., Hamazaki, T., Hammarskjold, B., Hynes, R. O., ... & Okuyama, H. (2016). Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open, 6(6), e010401. doi:10.1136/bmjopen-2015-010401.</li>
			<li>CEBM Response: Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review: A post-publication peer review. (2016). Centre for Evidence-Based Medicine. Retrieved from CEBM.</li>
			<li>Duncan, M. S., Vasan, R. S., Xanthakis, V., & Peterson, L. R. (2019). Trajectories of Cardiovascular Disease Risk Factors Across the Adult Life Course and Risk of Cardiovascular Disease and All-Cause Mortality: A 35-Year Framingham Study. Journal of the American Heart Association, 8(11), e011638. doi:10.1161/JAHA.119.011638.</li>
			
		</ol>
	</div>

Cholesterol has been a subject of debate in cardiovascular health. Despite its crucial role in various bodily functions, questions persist about its association with atherosclerotic cardiovascular disease (ASCVD).

Despite the abundance of evidence linking cholesterol to ASCVD, misconceptions persist. Understanding the facts about cholesterol and its impact on cardiovascular health is crucial for making informed decisions about managing your health.

Cholesterol Myths Debunked

Cholesterol

Debunking Common Cholesterol Myths

<ul style="font-size:.95em; font-weight:600; border: 2px dotted #5ba2b6; padding: 40px 5% 5px;">
		
		<li style="line-height:1.6; margin-bottom:25px;">CBD can interfere with how your body breaks down certain statins.</li>
		
		<li style="line-height:1.6; margin-bottom:25px;">This interference can cause statin levels in your blood to become too high.</li>
		
		<li style="line-height:1.6; margin-bottom:25px;">Higher statin levels increase the risk of side effects, such as muscle pain and weakness, potential liver enzyme changes, and increased fatigue and nausea.</li>
		
		<li style="line-height:1.6; margin-bottom:25px;">The likelihood of interaction can depend on the dosage and frequency of CBD use.</li>

		<li style="line-height:1.6; margin-bottom:25px;"><a href="https://www.marleydrug.com/zypitamag">ZYPITAMAG</a> and pravastatin have reduce potential for interactions with CBD and THC than other statins.</li>
	</ul>
	
	
	<br>
	
	
	<p>CBD (cannabidiol) has gained popularity as many adults explore its potential benefits for sleep, anxiety, and various forms of discomfort. Simultaneously, statins are the first-line treatment option for <a href="https://www.marleydrug.com/condition/high-cholesterol">managing cholesterol</a>. A large percentage of adults, particularly those over 75, rely on statins to reduce their risk of heart disease.</p>
	
	<p>Given the widespread use of both CBD and statins, it's not uncommon for individuals to take them at the same time.</p>
	
	<p>While CBD is often perceived as safe, it's important to understand that it can influence how your body processes other medications. When CBD is in your system, it may slow down how quickly statins are cleared from your body. This can cause statin levels to rise, which may lead to stronger side effects or reduce how well the medication works over time.</p>
	
	
	
	
	
	<h3>What Are CBD?</h3>
	
	<p>CBD (cannabidiol) is a natural compound found in cannabis plants. It's one of over 100 similar compounds called cannabinoids. Two most well-known cannabinoids are CBD and THC.</p>
	
	<p>THC is the part of cannabis that can make you feel “high”, or dizzy, or give you a sense of euphoria. CBD does not have that effect. It does not change how you feel in the same way. This is one reason why many feel more comfortable using CBD.</p>
	
	<p>CBD is used in various forms like oils, capsules, and creams by people who have issues with sleeping, anxiety, and pain. </p>
	
	<p>It's important to know that even though it's plant-derived, CBD is considered a drug because it can affect your body and how it processes other medications.</p>
		
	
	
	<h3>What Are Statins?</h3>
	
	
	<p>Statins are a class of medications commonly prescribed to help manage cholesterol levels. They work by blocking an enzyme in the liver that is needed to produce cholesterol.</p>
	
	<p>Cholesterol is a waxy substance essential for the body in small amounts, but high levels can increase the risk of heart disease and stroke. </p>
	
	<p>Statins affect different parts of cholesterol:</p>

	<ul>
		<li style="line-height:1.8; margin-bottom:15px;">Lower "bad" cholesterol (LDL)</li>
		
		<li style="line-height:1.8; margin-bottom:15px;">Slightly raise "good" cholesterol (HDL)</li>
		
		<li style="line-height:1.8; margin-bottom:15px;">Reduce triglycerides (a type of fat in the blood)</li>
	</ul>
	
	<p>There are 7 statins available</p>
	
	<ul>
		<li style="line-height:1.8; margin-bottom:10px;"><a href="https://www.marleydrug.com/blog/atorvastatin-lipitor">Atorvastatin (Lipitor)</a></li>
		
		<li style="line-height:1.8; margin-bottom:10px;"><a href="https://www.marleydrug.com/blog/a-guide-to-taking-rosuvastatinr">Rosuvastatin</a> (Crestor)</li>
		
		<li style="line-height:1.8; margin-bottom:10px;"><a href="https://www.marleydrug.com/blog/simvastatin-zocor">Simvastatin</a> (Zocor)</li>
		<li style="line-height:1.8; margin-bottom:10px;"><a href="https://www.marleydrug.com/blog/pravastatin-pravachol">Pravastatin</a> (Pravachol)</li>
		
		<li style="line-height:1.8; margin-bottom:10px;"><a href="https://www.marleydrug.com/blog/lovastatin-altoprev">Lovastatin</a> (Mevacor)</li>
		
		<li style="line-height:1.8; margin-bottom:10px;">Fluvastatin (Lescol)</li>
		<li style="line-height:1.8; margin-bottom:10px;">Pitavastatin (<a href="https://www.marleydrug.com/zypitamag">Zypitamag</a>)</li>
	</ul>
	
	<p>While each statin works slightly differently, their main goal is to improve cholesterol levels and reduce harmful fats in the bloodstream.</p>
	
	
	<h3>How CBD and Statins are Processed in Your Body</h3>
	
	
	<p>Both CBD and statins are metabolized in your body, primarily in the liver, before they can fully work or be removed. This process involves a group of enzymes known as the cytochrome P450 system, which helps your body process medications and eliminate them once they've done their job.</p>
	
	<h4><strong>Key Enzyme: CYP3A4</strong></h4>
	
	<p>CBD is broken down by several enzymes, especially CYP3A4. This same enzyme also metabolizes certain statins, such as atorvastatin (Lipitor) and simvastatin (Zocor). Because both CBD and some statins use this same pathway, taking them together can cause them to interfere with each other.</p>
	
	<h4><strong>CBD's Unique Effect</strong></h4>
		
	<p>CBD not only gets broken down by CYP3A4 but also inhibits this enzyme, slowing its activity. As a result, statins might stay in your body longer than they should, potentially causing their levels to build up. However, this does not happen with all statins; some are metabolized through different pathways and are less likely to be affected by CBD.</p>
	
	
	<h4><strong>Other Enzymes Involved</strong></h4>
	
	<p>CBD may also inhibit other liver enzymes, such as CYP2C19, CYP2D6, and CYP2C9, which are involved in processing statins like rosuvastatin, and many other medications. This means CBD can alter how quickly or slowly different medications are cleared from your body, depending on which enzymes they rely on.</p>
	
	<h4><strong>Interaction Between CBD and Statins</strong></h4>
	
	<p>When CBD and certain statins are taken together, they may compete for the same processing pathway, leading to higher statin levels in your body than expected, even if the dose has not changed.</p>
	

	
	
	
	<h3>Why Combining CBD with Certain Statins Can Be Risky</h3>
	
	<p>The main issue is that CBD can interfere with how your body breaks down certain statins, causing the statins to build up to higher levels than normal, which increases the risk of side effects.</p>


	
		
	<h5><strong>Muscle Pain or Weakness</strong></h5>
	
	<p>You might notice unusual muscle soreness, aches, or general weakness. Elevated statin levels can irritate your muscles, leading to these symptoms. This is a relatively common side effect when a statin dose becomes too strong for an individual.</p>
	
	
	
	<h5><strong>Severe Muscle Damage (Rhabdomyolysis)</strong></h5>
	
	<p>In rare instances, very high statin levels can lead to a serious condition called rhabdomyolysis. This involves a dangerous breakdown of muscle tissue, causing significant muscle pain. A key sign can be dark-colored urine due to muscle proteins entering the urine. While uncommon, rhabdomyolysis can be life-threatening and potentially damage your kidneys if not promptly treated.</p>
	
	<h5><strong>Liver Enzyme Changes</strong></h5>
	
	<p>Statins can sometimes affect your liver function. If too much statin builds up in your system, blood tests might reveal changes in liver enzyme levels, indicating liver irritation. In rare cases, this can progress to liver damage. Signs of liver issues could include yellowing of the skin or eyes (jaundice) or dark urine, although mild enzyme changes often don't cause noticeable symptoms.</p>
	
	<h5><strong>Other symptoms</strong></h5>
	
	<p>You might experience additional side effects if your statin levels are elevated. Some individuals have reported increased fatigue or nausea when their statin dose effectively becomes too high due to an interaction. These symptoms can be subtle but warrant attention if you start using CBD while on a statin.</p>
	
	<h5><strong>Overall Consideration</strong></h5>
	
	<p>Most patients taking statins do not experience severe side effects, but the likelihood of side effects can increase if the drug’s level in your body is higher than intended. That’s why it’s important to be cautious when adding something like CBD that could affect those levels.</p>
	
	<p>CBD’s impact on drug breakdown can vary based on how much CBD you use and how often you use it. The effect is dose-dependent. For example, small occasional doses of CBD may have little to no noticeable impact on your statin, whereas high doses or very frequent use of CBD are more likely to cause a stronger interaction.</p>
	
	
	<h3>Speak with Your Doctor</h3>
	
	<p>If you’re taking a statin and thinking about using CBD, or if you’re already using both, it’s important to talk with your doctor or pharmacist. Even though CBD may seem harmless or low- risk, it can still change how your body deals with certain medications, including some statins.</p>
	
	<p>Your doctor can help you figure out if the statin you’re taking is one that might interact with CBD. In some cases, they may recommend using a different statin that’s less likely to be affected, adjusting your dose, or checking your liver and cholesterol levels more often.</p>
	
	
	<div style="font-size:.85em; border-top:1px dotted #747474; margin-top:50px; padding-top:30px;">
		<p style="margin-bottom:10px;"><strong>References:</strong></p>
		
		<ol>
			<li>Gu Q, Paulose-Ram R, Burt VL, Kit BK. Prescription cholesterol-lowering medication use in adults aged 40 and over: United States, 2003–2012. NCHS Data Brief. 2014;(177):1-8. Available from: https://www.cdc.gov/nchs/products/databriefs/db177.htm</li>
		</ol>
	</div>

Both CBD and statins are metabolized in your body, primarily in the liver, before they can fully work or be removed. This process involves a group of enzymes known as the cytochrome P450 system, which helps your body process medications and eliminate them once they've done their job.

Mixing CBD and statins? Understand the potential problems, including increased risk of side effects from statins due to CBD's impact on drug processing in the body.

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Get Generic Brilinta (ticagrelor) Delivered

Generic Brilinta Now Available at Marley Drug

About Brilinta (ticagrelor)

On a recent survey, 99% of our customers answered they would recommend Marley Drug to a family member or friend.

What Our Customers Have to Say

Patty S.

Mark T.

Shirley F.

Theresa S.

Amy W.

How to Order Generic Brilinta (ticagrelor)

Provide us your prescription details

We'll verify your prescription

Your medication will be shipped to your home

Have medication questions for Generic Brilinta (ticagrelor)?Talk with a pharmacist today.

Brilinta (ticagrelor) Commonly Asked Questions

How Paying Cash for Your Prescriptions Can Cost Less Than Your Copay

Debunking Common Cholesterol Myths

Can You Take CBD With Statins? What You Need to Know

Have medication questions for Generic Brilinta (ticagrelor)?
Talk with a pharmacist today.