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Metformin Not Enough? What Else Can Be Done to Lower Your A1C Levels?


When metformin medication alone is not enough to control your A1C levels, it's time to consider combination therapy. While the high cost of additional medication can be a barrier for many Americans, ZITUVIO offers a powerful and affordable solution.

Type 2 Diabetes affects 37.3 million Americans — when it is not managed properly it can lead to complications such as heart disease, organ damage and nerve damage. Management often requires a multifaceted approach, including changes to your lifestyle and in some cases use of prescription medications. The first prescription medication your healthcare provider will likely turn to is metformin.

But, if metformin isn't enough to get your A1C levels to your target goal, your doctor may suggest combination therapy with another oral medication.

Over the past decade several medication classes have become available. Each have their own unique mechanism of action and safety and benefits profile. Because metformin is the first-line treatment option for managing type 2 diabetes the majority of these newer medication classes have all been studied as add-on therapy to metformin to help manage blood glucose levels in those with type 2 diabetes.

The problem with these new medications is with access—most cost upwards of $500/month. That was until recently, when ZITUVIO (sitagliptin), an SGLT-2 inhibitor, became available in the U.S. in 2023.

Through a partnership with the manufacturers of ZITUVIO, we are excited to offer this new medication for just $80/month—80% less than the cost of other branded medications from the same drug class.

Why Choose ZITUVIO (sitagliptin)?


Effective and Well-Tolerated
  • Blood Sugar Control: ZITUVIO is an oral prescription medication that helps regulate blood sugar levels by enhancing the body's natural ability to control blood sugar. The higher your blood sugar levels, that harder it works thanks to its mechanism of action (see below).
  • Enhanced Results with Metformin: When combined with metformin, ZITUVIO has been shown to lower hemoglobin A1C levels by an additional 0.7%.

Cost-Effective Solution—80% Less than other Brand Options
  • Affordable Therapy: Our pharmacy offers ZITUVIO (sitagliptin) at a much lower cost than other branded oral medications, making it a budget-friendly option.

Convenient and Easy to Use
  • Simple Oral Medication: ZITUVIO is taken once-daily with or without food, making it easy to incorporate into your daily routine.

How does ZITUVIO (sitagliptin) work?


ZITUVIO works by:

  • Enhancing Insulin Production: Increases insulin release from the pancreas when blood sugar levels are high..
  • Decreasing Sugar Production: Reduces the amount of sugar made by the liver.
  • Adapting to Your Needs: Intensifies its blood sugar-lowering efforts when your levels are elevated and moderates when they are lower, minimizing the risk of hypoglycemia (excessively low blood sugar).

How to Get ZITUVIO

Order online or over the phone

If you run into issues, just give us a call at 800-810-7790.

We will verify your prescription

We can contact your doctor for the prescription.

We will ship it to your home

Ship through USPS First Class Mail to all 50 states. Our average delivery time is 2 days.

Hear from our Customers

I really love Marley’s quick responses and the fact that I can purchase a 6 month supply rather than running to the drugstore every 30/90 days. The staff is wonderful, helpful and knowledgeable. I love ...
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Patty S.
The Wholesale Price List made my prescription easy to afford, I was about to cancel my prescription because my monthly cost with insurance was almost $150! Now I can get a 6-month supply for only $37 ...
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Mark T.
Check out this mail in pharmacy. My cardiologist referred me to them for best price on cholesterol lowering med. I found them to be helpful, professional and provide prompt service.
Theresa S.
As soon as my doctor submitted the prescription, I was contacted by Terri, who explained the process and set up delivery to my home. It could not have been easier!
Amy W.
Stock photos are used to represent actual testimonials of Marley Drug customers.

Have medication questions?
Talk with a pharmacist today.

Call us for a free pharmacy consult.

800-810-7790