Are you not meeting your cholesterol goals with pravastatin?
Switch to Zypitamag
$34.50/month minus the insurance hassle
Key Features of Zypitamag (pitavastatin)
- Similar metabolism to pravastatin
- Superior in LDL-C reduction compared to pravastatin
- Reduces LDL-C up to 45% and increases HDL-C up to 7%
- Compatible with grapefruit juice
- Taken once daily, with or without food
Pravastatin is a great option for individuals on multiple medications due to its unique metabolism pathway. Unlike most medications that rely on the same group of liver enzymes for processing, pravastatin takes a different route during breakdown. This differentiation reduces the potential for harmful drug interactions that often occur when numerous medications are involved.
However, pravastatin’s safety profile comes with a trade-off in terms of potency. Pravastatin is a low- to moderate-intensity statin, and many people may not reach their cholesterol targets with it.
Zypitamag (pitavastatin) is a stronger statin with a similar metabolism. Zypitamag is superior in LDL reduction without sacrificing the safety profile. Similar to pravastatin, Zypitamag bypasses the commonly used enzyme family, resulting in a reduced risk for drug and food interactions.
Zypitamag is metabolized in a similar manner to pravastatin
Drug interactions have a lot to do with how our body metabolizes them.
Most statins are processed by our body through an enzyme family called cytochrome 450, or CYP450 for short. 70-80% of drugs are also metabolized by this pathway.
Both Zypitamag and pravastatin bypass this pathway. As a result, both Zypitamag and pravastatin have reduced potential to interact with other medications compared to the other statins.
Easy Access To Zypitamag
- $34.50/month—cash price
- Free first 30 day supply with free shipping
- No pre-authorization
- No step-therapy
- No insurance hassles
Claim your free 30-day supply of Zypitamag!
If you don't have a prescription, request one with this form and we'll contact your doctor.
3 Studies Show Zypitamag is Superior to Pravastatin in Lowering Cholesterol
Several studies have compared Pitavastatin and Pravastatin's ability to lower cholesterol.
Before delving into the data yourself, here's a simple guide to help you understand this information:
- LDL-C (Low-Density Lipoprotein Cholesterol): Often known as 'bad cholesterol'. It's a type of cholesterol that can contribute to artery blockages and heart issues.
- HDL-C (High-Density Lipoprotein Cholesterol): Often called 'good cholesterol'. Having higher levels of HDL-C is generally beneficial for heart health, as it helps remove excess cholesterol from the blood vessels.
- Triglycerides: These are a kind of fat found in your bloodstream. High triglyceride levels are linked to a greater risk of heart disease.
- ApoB (Apolipoprotein B): This serves as a marker for cholesterol that can lead to artery clogging, forming plaques on the artery walls. Higher ApoB values indicate an increased risk of developing heart-related problems like atherosclerosis (narrowing of arteries) and potentially heart attacks.
- hsCRP (High-Sensitivity C-Reactive Protein): This acts as a sign of inflammation in the body. Elevated hsCRP levels are associated with an increased likelihood of heart disease.
STUDY 1
Lowering Cholesterol In Adults
Pitavastatin has shown a superior ability to lower LDL-cholesterol compared to pravastatin in adults with high cholesterol1-2.
Mean percent changes at week 12
| Pitavastatin 4 mg |
Pravastatin 40 mg |
|
| ApoB | -27% | -18% |
| Triglycerides | -16% | -13% |
| HDL-C | +5% | +6% |
STUDY 2
Lowering Cholesterol In Adults 65 years and older
Pitavastatin has shown a superior ability to lower LDL-cholesterol compared to pravastatin in those with high cholesterol who were older than 65 years of age 3.
Mean percent changes at week 12
| Pitavastatin 4 mg |
Pravastatin 40 mg |
|
| ApoB | -37% | -28% |
| Triglycerides | -22% | -15% |
| HDL-C | +4% | +1% |
| hsCRP | -0.9% | +0.6% |
STUDY 3
Lowering Cholesterol In Those Living With HIV
Managing HIV is now possible with new drug developments. Unfortunately, it means patients are taking a lot of medications which can increase drug interactions. Pitavastatin and Pravastatin are both acceptable options give their unique metabolism.
Pitavastatin has shown a superior ability to lower LDL-cholesterol compared to pravastatin in those with high cholesterol who were living with HIV4.
Mean percent changes at week 12
| Pitavastatin 4 mg |
Pravastatin 40 mg |
|
| ApoB | -26% | -19% |
| Triglycerides | -3% | -4% |
| HDL-C | +5% | +6% |
| hsCRP | -12% | 0% |
Claim your free 30-day supply of Zypitamag!
If you don't have a prescription, request one with this form and we'll contact your doctor.
References