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Experiencing Statin Muscle Pain?

62% of former statin users said side effect was the reason they stopped taking their statin1.

If you're facing similar challenges, there's good news for you. Ask our pharmacists about the next-generation statin—Zypitamag.

Zypitamag (pitavastatin)

The incidence of muscle pain associated with Zypitamag stands at just 3.1%

What causes statin muscle pain?

Muscle discomfort is one of the most common complaints from patients who take statins.

Researchers don’t understand the exact cause of statin-related muscle pain. What we do know is that the risk is closely linked to the dosage administered. The risk increases with higher doses of statins.

Higher Dose Statins Cause Higher Rates of Muscle Pain

While statin doses generally range from 5 mg to 80 mg, Zypitamag is available in 2 mg and 4 mg dose options, representing the lowest dosages available among statins.

Rate of Muscle Pain (%)
Zypitamag 2 mg Zypitamag 4 mg Placebo
2.8% 3.1% 1.4%

Compare statin-related muscle pain rates

Efficacy of Zypitamag

With Zypitamag, bad cholesterol is reduced by an average of 45%, while good cholesterol is increased by 7%.

In clinical studies, this has shown to be comparable to 20 mg atorvastatin, 40 mg simvastatin, and better than 40 mg pravastatin.

Compare efficacy of statins

People We've Helped

I just had my 3 month follow up blood work done for my cholesterol after using Zypitamag. The results were outstanding! The best lipid levels I have had in treating cholesterol... I have not had any side ...
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Garrick M
Before taking Zypitamag, I was on another statin which gave me some side effects. I am grateful to Marley drugs for making this drug so cost-effective and for the excellent home delivery service they offer ...
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Maria R.
Having experienced multiple moderate side effects from the “statin” I was prescribed, I sought help from my PCP. I was prescribed Zypitamag. The side effects quickly resolved, cholesterol levels have decreased ...
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Sherril H.
I have always had trouble with statins. My doctor recommended Marley Drug’s statin, Zypitamag (pitavastatin), and I have been taking that with no side effects and my bad cholesterol has gone down significantly ...
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Jacquie N.
This drug is a miracle for me! I have tried every statin on the market with copious amounts of muscle pain weakness, back pain overall, and aching in every joint. My family has genetic high cholesterol ...
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Nurse from Houston, TX
Zypitamag has made a world of difference in my health. I have not had any side effects of muscle pain. Thank you, Marley Drug for making the process of getting this medication so fast and easy. I never ...
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Anne H.
I had tried to take several different cholesterol medicines and everyone of them made me ache and hurt real bad. So I would just stop taking them. My doctor was concerned because my cholesterol was above ...
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Beatrice Martin
Your personal experience with Zypitamag may differ. Talk to your healthcare provider to see if Zypitamag is right for you. Stock photos are used to represent actual testimonials.

Try Zypitamag today—Claim your free 30-day offer.
Call 800-810-7790

Don't have a prescription?
Download and fill out the form and we can request one from your healthcare provider on your behalf.

Zypitamag is Processed By Our Body Differently

Statins, like most medications, are metabolized by enzymes in our body. A family of enzymes, CYP450, processes 70-80% of medications. When these enzyme pathways become too busy, it can lead to drug interactions.

Zypitamag bypasses this enzyme family and is mainly processed by a less busy enzyme family. This process leads to a reduced potential for specific interactions with other medications.

Zypitamag uses a less busy enzyme pathway so it is less likely to cause problems with other medications you take. CYP450 stands for cytochrome P450 which is a common enzyme used to process 70-80% of medications. UGTs stands for uridine 5'-diphosphate glucuronosyltransferase (UGT) which is an enzyme that metabolizes pitavastatin by a process called glucuronidation.

Importance Of Managing Cholesterol

The role of cholesterol in the development of cardiovascular disease is well established. Statins are the first line of defense to lower cholesterol levels, particularly bad cholesterol, or LDL-C.

Over time, if you don't manage your cholesterol levels, it can build up on your artery walls and form plaques. When these plaques become too large, or if they rupture, they can result in blockage of blood flow to your organs, such as your heart or brain, which can result in a heart attack or stroke.


What If I Am Statin Intolerant?

Approximately 9% of people are statin-intolerant. If you are experiencing statin intolerance, there are multiple strategies your healthcare provider may try, including:

Most people can resume statin therapy successfully with above modifications. If a statin alone isn't enough to meet your cholesterol goal, your healthcare provider may recommend combination therapy.

There are many statin options. And every statin is different.

About Zypitamag, Next-Generation Statin

  • Decreases LDL (bad cholesterol) by 45%; increases HDL (good cholesterol) by 7%
  • Available in 2 mg and 4 mg tablets
  • Compatible with grapefruit juice (unlike some other statins)
  • Reduced potential for drug-drug interaction compared to other statins
  • Metabolized by our body differently than other statins
  • FDA-approved in 2017
  • Requires a prescription

Try Zypitamag today—Claim your free 30-day offer.
Call 800-810-7790

Don't have a prescription?
Download and fill out the form and we can request one from your healthcare provider on your behalf.

Statin Intolerance
Statin Intol​erance Affects 9.1% of Patients

Statin intolerance is when someone cannot take their statin therapy due to side-effects or adverse events they experience. Certain risk factors that increase your chances including:

  • Being female: 47.9% increase risk​
  • Increasing age: 33.1% increased risk​
  • Having hypothyroidism: 39.6% increased risk​
  • Being overweight: 30.6% increased risk

Learn more about additional statin intolerance risk factors here and what you can do.

Compare Statins
Factors to Consider when Choosing a Statin​

There are many important factors to consider when choosing a statin. Some things to discuss with your healthcare provider include:​

  • What statin intensity do I require?​
  • How will my body process the statin?​
  • What statin is the safest?​
  • Which statin has the fewest side effects?

Compare Statins

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1 Cohen JD et al. J Clin Lipidol. 2012;6(3):208-215