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Oct 25, 2023

Blood Pressure


Eplerenone (Inspra)

Eplerenone Uses

Eplerenone (Inspra)—pronunciation: uh·plur·uh·naan—is used for managing high blood pressure. It works by blocking aldosterone, a natural steroid hormone in the body which balances salts in the kidneys by releasing potassium and storing sodium.

This medication may also be prescribed to treat congestive heart failure and hyperaldosteronism (a condition where your body produces too much aldosterone).

Eplerenone Dosage

The typical starting dose for eplerenone is 50 mg once per day. This may change depending on your responsiveness to the medication.

Doses for children 4 years old and under are determined by the healthcare professional typically based on weight.

Eplerenone Side Effects

Common Side Effects

These eplerenone adverse effects are mild and usually short-lived as the body adjusts to the medication. If any of the following side effect become bothersome or last more than a few days speak to your pharmacist or healthcare provider:

  • Dizziness
  • Headaches
  • Cough
  • Trouble sleeping
Serious Side Effects

These side effects are rare but could indicate serious health complications. Speak to your healthcare provider immediately if you experience any of the following:

  • Irregular or fast heart rate
  • New/worsening chest pain
  • Allergic reaction: rash, difficulty breathing, swelling in face and throat


Some medications are known to affect the way eplerenone works or increase your chance of side effects. Speak to your healthcare provider about any current medications and new medications you may begin taking while on eplerenone.

Some medications that may interact with eplerenone are:

  • Other medications used to treat high blood pressure
  • Tacrolimus
  • Cyclosporine
  • Trimethoprim
  • Digoxin
  • Lithium
  • Warfarin
  • NSAIDs (e.g., ibuprofen, naproxen)
  • Medications that affect potassium (e.g., potassium supplements, spironolactone, amiloride)
Eplerenone and Alcohol

Alcohol can interact with eplerenone to increase drowsiness and effect reflexes and judgement. Alcohol also affects your blood pressure and heavy drinking can lead to heightened blood pressure. If you choose to drink, be sure to not exceed the daily recommended limit of 1 unit/day for women and 2 units/day for men.

Eplerenone Cost

On average, the price of eplerenone 25 mg is $125.63 for a one-month supply.

Get Eplerenone For Less at Marley Drug

Marley Drug offers the same eplerenone prescription with free shipping to all 50 states. See our price for eplerenone here.

Marley Drug saves you time and money on your prescriptions without sacrificing patient care. Our pharmacy team is available 24/7 to answer your questions or concerns.

Call us today at 1 800-810-7790 and learn more about what Marley Drug has to offer.

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