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Jul 8, 2024

Men's Health

Testosterone Replacement: Differences Between Kyzatrex and TLando

Low Testosterone

Testosterone is essential for normal development and the proper functioning of many bodily processes. A lack of testosterone can lead to changes in cognitive, sexual, and physical functions, often resulting in uncomfortable or unwanted symptoms such as:

  • Lack of energy
  • Low sex drive
  • Depression and/or anxiety
  • Decreased muscle mass
  • Weight gain
  • Difficulty sleeping

While these symptoms can be caused by low testosterone, they may also result from other medical conditions. Therefore, it is crucial to speak with a healthcare provider for a thorough assessment and diagnosis before starting any treatment for low testosterone. This ensures that the right cause is identified and appropriately treated.

Kyzatrex vs TLando

When diagnosed with hypogonadism (low testosterone levels), the typical treatment involves replacing testosterone. There are several ways to supplement the hormone: injections, topical gels, and oral capsules.

For many years, testosterone replacement therapy (TRT) predominantly relied on injections. However, in 2019, testosterone undecanoate (TU) became available in oral form, offering a more convenient option. TU is easy to take and avoids the need for injections, making it appealing for men seeking hormonal balance.

In this article, we will compare two oral testosterone products: Kyzatrex and TLando.

Important Safety Information

Neither Kyzatrex nor TLando should be used by:

  • Individuals with suspected or known prostate cancer.
  • Women who are pregnant.
  • Individuals with low testosterone levels due to non-physical or non-genetic causes.

By understanding the differences and benefits of these two oral testosterone treatments, men with hypogonadism can make more informed decisions about their health.

How Do Kyzatrex and TLando Work?

Kyzatrex and TLando both work by increasing testosterone levels in your body. Historically, developing oral testosterone medications has been challenging due to difficulties with absorption. Generally, oral testosterone passes through the liver, which can inactivate the hormone. There were also concerns about liver damage from earlier products, but newer medications have addressed this issue.

Understanding Testosterone Undecanoate

Testosterone undecanoate (TU) is a form of oral testosterone designed to overcome absorption challenges. Instead of being processed through the liver, TU uses fats from the food you eat to be absorbed into the body. This method allows the testosterone to enter the lymphatic system, bypassing the liver and effectively increasing testosterone levels.

Dose and Administration

Both TLando and Kyzatrex are taken orally, twice a day. However, the strengths of the medications differ.

  • TLando: Each capsule is 112.5 mg. You take two capsules per dose, totaling 225 mg twice a day.
  • Kyzatrex: Comes in three strengths: 100 mg, 150 mg, and 200 mg. This variety allows for more flexible dosing.

While TLando's single dosing strength may work well for many people, Kyzatrex's flexibility in dosing options might be preferable for others, allowing for more personalized treatment.

Side Effects

Due to the nature of these medications, side effects should be monitored before and throughout treatment. The most common side effect for both TLando and Kyzatrex is an increase in blood pressure. This needs to be carefully monitored to ensure the medication remains safe to use. Extra consideration should be taken before starting these medications in individuals with risk factors or already significantly elevated blood pressure.

In clinical studies on TLando, some additional side effects were observed. These include changes in certain blood levels, such as:

  • Increase in Prolactin: This hormone can affect reproductive health and may cause issues like reduced sex drive or breast enlargement in men.
  • Increase in Hematocrit: This means more red blood cells, which can thicken the blood and increase the risk of blood clots.

The importance of these changes varies for each person, so it's crucial to monitor these levels and discuss any concerns with your healthcare provider.

Severe Risks of Medications

TLando and Kyzatrex both contain the same active ingredient (testosterone undecanoate). As with most medications, the use of these products comes with some rare but serious risks. These risks are the same for both medications, and includes but is not limited to:

  • Worsening benign prostatic hyperplasia (BPH): Individuals who have BPH should be monitored closely while initiating testosterone products to assess for worsening symptoms of the condition.
  • Increased risk of a venous thromboembolism (blood clot): The use of testosterone products may possibly increase the risk of a blood clot, and therefore should be monitored for, particularly in individuals with increased risk factors.
  • Increased risk of sleep apnea: Testosterone products may increase the risk of developing sleep apnea, particularly in individuals who are already at risk of developing the condition.
  • Fertility changes: There is a potential for testosterone products to result in reduced sperm production (azoospermia), which may have an impact on fertility.
  • Medication overuse: Testosterone is a controlled substance and should only be taken at the dose prescribed. If you are at risk of/considering using more medication than prescribed, speak with your healthcare provider to ensure you are maintaining safe use of your medication.

Overall, the potential risks involved with taking either testosterone product is similar, and the decision should take into account factors relating to your individual health.

Retail Cost

The price difference between TLando and Kyzatrex is significant:

  • TLando: 120 capsules cost about $900.
  • Kyzatrex: 120 capsules cost $159, regardless of the strength.

This price difference becomes even more notable when considering the dosage.

  • TLando: Requires two capsules per dose, effectively doubling the cost over the same period.
  • Kyzatrex: Requires only one capsule per dose.

For a 60-day supply, TLando would cost approximately $1800, while Kyzatrex would still cost $159, making Kyzatrex a much more affordable option.

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