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Jul 12, 2022

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Synthroid or levothyroxine. Which is better?

What is Levothyroxine?

Levothyroxine is a generic version of Synthroid, Levoxyl, Unithyroid, Tirosint, and Euthyrox, among other names. Both generic and brand name medications are used to treat “hypothyroidism”, a condition where your body is not producing enough “thyroid hormone”. Your thyroid hormones control many of your bodily functions, so not having enough can cause many problems. Levothyroxine is the go-to treatment for hypothyroidism and works by “replacing” the missing thyroid hormones in your body.

Learn more about using levothyroxine to treat low thyroid (hypothyroidism).


Levothyroxine comes in a wide range of doses. This may be confusing to some people.

What is the normal dose?

There is no “normal” dose, and patients are often prescribed a few different doses before they find which one works best for them. Patients usually start at the lowest dose and work their way up until they find the right dose. Even a small change makes a big difference, which is why there are many different doses available for levothyroxine.

Generic levothyroxine tablets are available in a range from 25 mcg to 300 mcg at Marley Drug.

Is a higher dose more expensive?

The price of levothyroxine can vary greatly depending on the dose. This can be frustrating as the dose that works for you may be far more expensive than other available doses.

Levothyroxine 75 mcg: $12–$25
Levothyroxine 300 mcg: $18–$48
If you are on levothyroxine 300 mcg you could be paying almost double the price of 75 mcg

With coupons and online pharmacy options you can get levothyroxine at affordable prices between $4 and $13. You should pay attention to available doses though. Often these prices don’t include 300 mcg and you will see a price jump for it.

We keep one price for levothyroxine regardless of the dose.

At Marley Drug a 75 mcg dose costs the same as a 300 mcg dose. This gives you the flexibility in choosing the right dose for you without worrying about any additional costs! Levothyroxine is on our Wholesale Price List: $70 for 12 months or $37 for 6 months.

Generic Levothyroxine vs Synthroid

Levothyroxine is available as either brand name (e.g. Synthroid) or generic versions. Neither the brand name nor generic levothyroxine is better than the other. It depends on individuals. Although the active ingredient—levothyroxine sodium—is the same, the inactive ingredients can affect how your body absorbs the medication. Once you’ve found the right one for you it’s best to stick with it for consistency.

There is also cost to consider. Many patients are unknowingly paying more by choosing the brand name product.

With a Synthroid Savings Card patients are paying $25 per month, and without the card a whopping $52–$79 per month! That means you could be paying more for one month of Synthroid than for 12 months of generic levothyroxine at Marley Drug.

Why you should stick to the same manufacturer of Levothyroxine

Levothyroxine has a narrow therapeutic range, which means that small changes in the medication ingredients or dosages can alter how well the medication works for you. Because of this, it’s recommended to use the same manufacturer for levothyroxine each time.

When you get a generic version of levothyroxine at a typical pharmacy, the pharmacist has multiple generic products to choose from. Patients can’t be sure that they are getting the same generic every time they refill the prescription.

Getting a 6- or 12-month supply ensures consistency with the formula of levothyroxine and allows you to be sure you are staying at the same dose for the best possible effect of the medication

Switching from Synthroid to Generic Levothyroxine?

While it is not recommended to change back and forth between generic and brand name, it is completely fine to switch from one to the other. However, when switching from brand to generic it’s best to talk with your healthcare provider first, so you can monitor any potential changes in your thyroid levels.

How Marley Drug keeps low price

Over 100 generics are on our Wholesale Price List for $70/year or $37 for 6 months. The list is beneficial for for patents who are on long-term maintenance medications. A fixed price and longer fills guarantee you have consistent supply of your medication without price fluctuations. We can keep the low price because we price our medications based on what it costs us to buy them, not based on the price decided by your insurance.

By accessing our medications directly from accredited wholesalers, we are able to cut out the insurance company middlemen who usually hike up the costs of drugs with their arbitrary “service fees”. Because of this our prices are competitive, and often better than most insurance plans especially for longer fills.

Why filling in longer supply is better for you

Levothyroxine is usually taken for life. Once you’re on a steady dose, filling in longer supply means you will have access to a consistent supply of medication from the same drug manufacturer. This ensures consistency in the medication you’re taking.

It also means:

  • Fewer pharmacy visits
  • You'll experience less hassle
  • You'll have lower out-of-pocket costs for you

How to order levothyroxine from Marley Drug

You can order levothyroxine right to your door in 3 quick and easy steps.

  1. Search for levothyroxine and provide your medication details.
  2. We will contact your healthcare provider to confirm your prescription.
  3. The medications are shipped right to your door at no additional cost!

Order Levothyroxine

You can even add other prescriptions to your order and get all your prescription needs in one order!

Call 800-810-7790 for more information on how to get generic levothyroxine sent to your home at half the cost!

Prices mentioned in this article are based on average retail price at major box chain pharmacy in the U.S. as of June 19, 2022.

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