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<h2><strong>What is Bupropion (Wellbutrin)?</strong></h2><p>Bupropion is an antidepressant medication that helps to treat various forms of anxiety and depression. The two mental health conditions approved for treatment are:</p><ul><li>Major depressive disorder (MDD)</li><li>Seasonal Affective Disorder (SAD)</li></ul><p>It is also prescribed to help people quit smoking (<strong>smoking cessation</strong>).</p><p><br></p>
<h2><strong>Common Questions about Bupropion</strong></h2>
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<h2><strong>Bupropion, Bupropion SR, and Bupropion XL are all on Marley Drug’s Wholesale Price List</strong></h2><p>Our Wholesale Price List offers affordable pricing on many commonly prescribed generics. This means that regardless of the type or dose of Bupropion you are prescribed, the price will be the same. If you buy more, you save more. We offer <strong>Bupropion and 100  other medications for less than $6/month</strong> if you buy in a 12-month supply; just $70.</p><p><a href="https://www.marleydrug.com/wholesale-price-list-medications" rel="noopener noreferrer" target="_blank">Check our&nbsp;full list</a></p>

<p class="ql-align-center">Through our online portal you can provide us your medical history and prescription details. Questions? Call <a href="tel:1-800-810-7790" rel="noopener noreferrer">800-810-7790</a>.</p>

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<h2><strong>How does Bupropion (Wellbutrin) work?</strong></h2><p>Bupropion is an atypical antidepressant medication. It works by inhibiting the reuptake of three chemicals in our brain that help with our mood; dopamine, serotonin, and norepinephrine. These chemicals are important to help stabilize our mood and bupropion helps to balance them out. </p>

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<p>Depression is classified as a mood disorder that may be described as feelings of loss, anger or sadness that interfere with one’s everyday activities. An estimated 1 in 15 adults (6.7%) experience depression in a given year. </p>

<p>On average, depression first appears during the late teens to mid-20s, although it can occur at any time. It has been shown that <strong>one-third of women will experience a major depressive episode at least once in their lifetime</strong>. There is also a high degree of heritability (approximately 40%) when immediate relatives such as parents or siblings have depression. </p>

<p style="padding:10px; border:2px dotted #efefef; background-color:#F1F4F4; text-align:center;">See our blog on <a href="https://www.marleydrug.com/blog/general-anxiety-disorder-medication" rel="noopener noreferrer" target="_blank">General Anxiety Disorder (GAD)</a></p>

<h3><strong>Signs and symptoms</strong></h3>

<p>Depression can appear in many different forms and usually depends on each individual person. They can vary in how often they appear, the severity of the symptoms, as well as how long these feelings last for. If you have experienced some of the following signs and symptoms nearly everyday for at least 2 weeks, you may be living with depression:</p>

<ul>
<li style="margin-bottom:5px;">Feeling sad or “empty”</li>
<li style="margin-bottom:5px;">Feeling bothered, annoyed or angry</li>
<li style="margin-bottom:5px;">A loss of interest in hobbies you once enjoyed</li>
<li style="margin-bottom:5px;">Decreased energy levels</li>
<li style="margin-bottom:5px;">Difficulty sleeping</li>
<li style="margin-bottom:5px;">Thoughts of death, suicide or self-harm </li>
</ul>

<br>
<img src="https://marley-storage.imgix.net/c8f19f90-7ddc-4c88-bfa8-457e0da84836/BL-depression-symptoms.png" alt="Depression Symptoms">
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<h3><strong>Depression risk factors</strong></h3>

<p>There are many factors that can affect one’s risk of developing depression. These can be biochemical, medical, social, genetic or circumstantial in nature. Some common risk factors include:</p>

<ul style="list-style-type:none; padding-left:0;">
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Sex:</span> Females are at higher risk of developing depression than men.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Genetics:</span> You have a higher risk of developing depression if a family member has also had depression. </li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Socioeconomic status: </span> This includes financial problems and perceived low social status.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Certain medications:</span> These may include hormonal birth control, <a href="https://www.marleydrug.com/blog/corticosteroid">corticosteroids</a> and <a href="https://www.marleydrug.com/blog/what-are-beta-blockers">beta-blockers</a>.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Vitamin D deficiency:</span>Low levels of vitamin D have been linked to depressive symptoms.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Gender identity:</span> Transgender people have a risk of depression nearly 4-fold higher than cisgender people. </li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Medical illness:</span> People with <a href="https://www.marleydrug.com/heart-disease">heart disease</a> are twice as likely to develop depression than people who don’t, and 1 in 4 people with cancer may experience depression. </li>
</ul>

<h3><strong><a href="https://www.marleydrug.com/blog/different-types-of-depression">Depression types</a></strong></h3>

<p>There are 2 major types of depression that differ by symptom severity and persistence. </p>

<p><span style="font-weight:600; color:#4b94a9;">Major depressive disorder (MDD):</span> This is the more severe form of depression and is characterized by persistent feelings of sadness, hopelessness and worthlessness that will not go away on their own. In order to diagnose someone with clinical depression they must experience 5 or more of the following symptoms over a 2-week period:</p>

<ul>
<li style="margin-bottom:5px;">Feeling depressed most of the day</li>
<li style="margin-bottom:5px;">Significant weight loss or gain</li>
<li style="margin-bottom:5px;">Loss of interest in most regular activities</li>
<li style="margin-bottom:5px;">Excessive sleeping or inability to sleep</li>
<li style="margin-bottom:5px;">Slowed thinking or movement</li>
<li style="margin-bottom:5px;">Fatigue most days</li>
<li style="margin-bottom:5px;">Feelings of worthlessness or guilt</li>
<li style="margin-bottom:5px;">Loss of concentration or indecisiveness </li>
<li style="margin-bottom:5px;">Recurring thoughts of death or suicide </li>

</ul>

<p><span style="font-weight:600; color:#4b94a9;">Persistent depressive disorder (PDD):</span> This is a milder form of depression but it is more chronic. In order to be diagnosed with this disorder your symptoms must be present for at least 2 years. Since these symptoms last longer than MDD, it can have a larger impact on your life. It is very common for people with PDD to lose interest in normal daily activities, feel hopeless, have low self-esteem and lack productivity. </p>

<p><span style="font-weight:600; color:#4b94a9;">Postpartum depression:</span> This is in a category of its own and usually refers to depression after childbirth. Postpartum depression affects 1 in 9 new parents. Surprising to most, <strong>this can affect both men and women</strong>. The symptoms usually appear 3-6 months after birth and if they last longer than 2 weeks you may be experiencing postpartum depression. Including the symptoms already listed previously you may also experience:</p>

<ul>
<li style="margin-bottom:5px;">Having thoughts of hurting the baby or yourself</li>
<li style="margin-bottom:5px;">Not having an interest in the baby as if your baby is someone else’s</li>
<li style="margin-bottom:5px;">Having memory problems</li>
<li style="margin-bottom:5px;">Withdrawing from friends and family</li>
</ul>

<h3><strong>Depression medication</strong></h3>

<p>Along with other treatments such as psychotherapy (talking to a therapist), medications are often prescribed to help alleviate some of the symptoms associated with depression. These include:</p>

<p><span style="font-weight:600; color:#4b94a9;">Selective serotonin reuptake inhibitors (SSRIs):</span> These are the most commonly prescribed <a href="https://www.marleydrug.com/blog/ssri-and-snri">antidepressants</a> because they tend to have fewer side effects. They treat depression by increasing the availability of the neurotransmitter's serotonin (happiness chemical). SSRIs include <a href="https://www.marleydrug.com/checkout/Citalopram"  target="_blank" style="color:#222222;">citalopram</a> (Celexa), <a href="https://www.marleydrug.com/checkout/Escitalopram" target="_blank" style="color:#222222;">escitalopram</a> (Lexapro), <a href="https://www.marleydrug.com/checkout/Fluoxetine"  target="_blank" style="color:#222222;">fluoxetine</a> (Prozac), <a href="https://www.marleydrug.com/checkout/Paroxetine" target="_blank" style="color:#222222;">paroxetine</a> (Paxil) and <a href="https://www.marleydrug.com/checkout/sertraline" target="_blank" style="color:#222222;">sertraline</a> (Zoloft). </p>

<p><span style="font-weight:600; color:#4b94a9;">Serotonin-norepinephrine reuptake inhibitors (SNRIs):</span> These treat depression by increasing the amount of the neurotransmitter’s serotonin and norepinephrine in your brain. SNRIs include <a href="https://www.marleydrug.com/checkout/Duloxetine" target="_blank" style="color:#222222;">duloxetine</a> (Cymbalta), <a href="https://www.marleydrug.com/checkout/khedezla~" target="_blank" style="color:#222222;">desvenlafaxine</a> (Khedezla) and <a href="https://www.marleydrug.com/checkout/Venlafaxine" target="_blank" style="color:#222222;">venlafaxine</a> (Effexor XR). </p>

<p><span style="font-weight:600; color:#4b94a9;">Tricyclic and tetracyclic antidepressants:</span> Both of these treat depression by increasing the amount of the neurotransmitter’s serotonin and norepinephrine in the brain. These can be very effective but tend to cause more severe side effects, so they are generally not prescribed unless you’ve tried an SSRI first. Medications in this category include <a href="https://www.marleydrug.com/checkout/Amitriptyline" target="_blank" style="color:#222222;">amitriptyline</a> (Amitid), <a href="https://www.marleydrug.com/checkout/Mirtazapine" target="_blank" style="color:#222222;">mirtazapine</a> (Remeron) and <a href="https://www.marleydrug.com/checkout/Nortriptyline"  target="_blank" style="color:#222222;">nortriptyline</a> (Pamelor). </p>

<p><span style="font-weight:600; color:#4b94a9;">Atypical antidepressant:</span> These medications don’t fit into any of the other categories of antidepressants but they treat depression in a similar manner. These include <a href="https://www.marleydrug.com/checkout/Bupropion" target="_blank" style="color:#222222;">bupropion</a> (Wellbutrin) and <a href="https://www.marleydrug.com/checkout/Trazodone"  target="_blank" style="color:#222222;">trazodone</a> (Desyrel). </p>

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<h3><strong>When to see a doctor</strong></h3>

<p>Depression is a highly stigmatized disease that a lot of people do not seek treatment for, in fact, 1 in 6 people (16.6%) will experience it in their lifetime. Depression has a variety of symptoms that affect each individual differently.</p>

<p>If you feel depressed, or think you feel depressed, make an appointment with your healthcare provider as soon as you can. Talking about it is the first step to getting your mental health back on track. </p>

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<div style="font-size:0.85em;">
<p><strong><h6>Data in this article was informed by:</strong><br>(1) Mayo Clinic (2) Healthline (3) Psychiatry.org</p>
</div>

<hr style="border-bottom: dotted 1px #efefef;">

Depression can appear in many different forms and usually depends on each individual person. They can vary in how often they appear, the severity of the symptoms, as well as how long these feelings last for. If you have experienced some of the following signs and symptoms nearly everyday for at least 2 weeks, you may be living with depression.

1 in 15 adults experience depression a year. Learn about depression symptoms, risk factors, treatment options, and when to seek help from a medical professional.

What Is Depression | Symptoms, Risks & Treatment Options

Mental Health

What Depression Is

<p style="font-size:1.35em; margin: 30px auto 30px auto; padding-left:15px; border-left:5px solid #fee203;"><em>Feeling anxious, nervous, or agitated? You’re not alone! General Anxiety Disorder (GAD) affects 6.8 million adults every year. Although GAD is among the most common mental illnesses in the United States, it can significantly affect your quality of life.</em></p>

<h2><strong>What is General Anxiety Disorder (GAD)?</strong></h2>

<p>Normally, individuals occasionally experience fear and worry when faced with situations at work, school, or home, such as taking an exam, speaking in public, or going for a job interview. You may even experience physical symptoms, such as increased heart rate, shortness of breath, upset stomach, insomnia, or fatigue. These symptoms of occasional anxiety come and go, tend to resolve once the temporary issue is over, and do not interfere with your daily life.</p>

<p>An <a href="https://www.marleydrug.com/blog/three-major-forms-of-anxiety">anxiety disorder</a> is different. When individuals have an anxiety disorder, they experience persistent or excessive symptoms that interfere with their ability to do well at school or work and can harm relationships. People with a generalized anxiety disorder (GAD) feel anxious and worried most of the time, and these worries may be chronic (long-term), severe, and can cause great distress.</p>

<p style="padding:10px; border:2px dotted #efefef; background-color:#F1F4F4; text-align:center;">See also our blog on <a href="https://www.marleydrug.com/blog/what-depression-is" rel="noopener noreferrer" target="_blank">What is Depression</a>.</p>

<h2><strong>Signs and Symptoms of GAD:</strong></h2>

<p >GAD is a type of anxiety disorder characterized by long-term anxiety, excessive worry, tension, and dread, even when nothing has occurred to trigger or provoke it.</p>

<p style="margin-bottom:5px;">GAD is marked by physiological and physical symptoms that persist for over 6 months and include:</p>

<ul>
<li style="margin-bottom:5px;">Rapid heartbeat (palpitations)</li>
<li style="margin-bottom:5px;">Feeling restless, or “on-edge”</li>
<li style="margin-bottom:5px;">Feeling shaky or weak</li>
<li style="margin-bottom:5px;">Easily tired and fatigued</li>
<li style="margin-bottom:5px;">Feeling irritable</li>
<li style="margin-bottom:5px;">Having difficulty concentrating</li>
<li style="margin-bottom:5px;">Difficulty controlling feelings of worry</li>
<li style="margin-bottom:5px;">Problems relaxing</li>
<li style="margin-bottom:5px;">Being easily startled</li>
<li style="margin-bottom:5px;">Having difficulty falling or staying asleep</li>
<li style="margin-bottom:5px;">Increased muscle aches, tension, and/or soreness (i.e. sore jaw or back)</li>
<li style="margin-bottom:5px;">Experiencing difficulty participating in everyday activities (i.e. work, study, seeing friends and family)</li>
<li style="margin-bottom:5px;">Headaches and/or light-headedness</li>
<li style="margin-bottom:5px;">Sweaty palms</li>
<li style="margin-bottom:5px;">Dry mouth</li>
<li style="margin-bottom:5px;">Trouble breathing</li>
</ul>

<h2><strong>How is GAD Diagnosed?</strong></h2>

<p>Symptoms must be present most days of the week for at least 6 months in order to receive a diagnosis of GAD. GAD is diagnosed with a mental health screening completed by your doctor or mental health professional. You may answer self-report questionnaires regarding your symptoms and how long you’ve had them, such as the <u>Generalized Anxiety Disorder Scale-7</u>, which will help your doctor identify the precise diagnosis and <em>severity </em>of GAD. Diagnosis may also include:</p>

<ul>
<li style="margin-bottom:5px;">Bloodwork and/or urine test, to examine hormone levels that may signify a thyroid disorder.</li>
<li style="margin-bottom:5px;">A gastric reflux test, for instance, an X-ray of your digestive system or an endoscopy procedure to examine your esophagus for <a href="https://www.marleydrug.com/managing-stomach-acid">GERD</a>.</li>
<li style="margin-bottom:5px;">Stress test, to check for heart conditions.</li>
<li style="margin-bottom:5px;">Physical exam, to check for signs indicating that your anxiety may be related to medications or an underlying medical condition.</li>
<li style="margin-bottom:5px;">Patient interview and/or psychological questionnaire to form medical history, symptom details, and determine a diagnosis.</li>
<li style="margin-bottom:5px;">An assessment of symptom criteria, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).</li>
</ul>

<h2><strong>What Causes GAD?</strong></h2>

<p>In many cases, a combination of factors can contribute to the development of GAD.</p>

<ol>
<li style="margin-bottom:20px;"><strong>Biological factors</strong>: Differences in brain chemistry and function.</li>

<li style="margin-bottom:20px;"><strong>Psychological factors</strong>: Particular personality traits can increase your risk of GAD. For example, being emotional or a distressed person, sensitive/fragile, having difficulty enduring irritation/annoyance, and having a personality that strives for flawlessness. Additionally, those that are more negative, have a timid character or tend to evade danger.</li>

<li style="margin-bottom:20px;"><strong>Family history</strong>: Genetics play a role in GAD when individuals have a history of mental health problems in their family.</li>

<li style="margin-bottom:20px;"><strong>Health conditions</strong>: Thyroid issues or heart arrhythmias.</li>

<li style="margin-bottom:20px;"><strong>Traumatic events</strong>: You may have an increased risk of developing GAD if you have experienced a severe life change that has caused nervousness, including grief, childbirth, or workplace-induced trauma. If you have experienced any form of abuse, such as emotional, physical, or sexual abuse, you may be more at risk of developing GAD.</li>
</ol>

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<h1><strong>Treatment Options for GAD</strong></h1>

<p>Treatment options are dependent on how much GAD is affecting your ability to function in your daily life. Various types of medications are used to treat GAD.</p>

<h4 style="color:#5ba2b6;"><strong>1. Antidepressants</strong></h4>

<p>Antidepressants are used as <em>first-line </em>medication options to treat GAD and relieve symptoms. These medications need to be titrated (built-up) in your system slowly to minimize anxiousness. SSRIs and SNRIs are used daily and <strong><em>do not provide immediate relief; takes at least 4 weeks or more </em></strong> for a noticeable effect.</p>

<p>When first starting <a href="https://www.marleydrug.com/blog/ssri-and-snri">SSRIs/SNRIs</a>, you may experience some unpleasant side effects, however, they generally decrease or go away after 4-8 weeks.</p>

<p style="margin-bottom:5px;">Common side effects include:</p>

<ul>
<li style="margin-bottom:5px;">Decreased libido (sexual arousal)</li>
<li style="margin-bottom:5px;">Drowsiness</li>
<li style="margin-bottom:5px;">Insomnia</li>
<li style="margin-bottom:5px;">Nausea—Taking your medication with food may reduce nausea</li>
<li style="margin-bottom:5px;">Diarrhea</li>
<li style="margin-bottom:5px;">Dry mouth</li>
<li style="margin-bottom:5px;">Headache</li>
<li style="margin-bottom:5px;">Dizziness</li>
</ul>

<h5><strong>Suicide Risk and Antidepressants:</strong></h5>

<p>Although most antidepressants are generally safe, the FDA requires that <strong>all </strong>antidepressants carry a <strong>black box warning </strong>(the strictest warnings for prescriptions) of a possible <strong>increase in suicidal thoughts or actions </strong>in some children, teenagers, or young adults under 25 within the first few months of treatment or when the dose is changed.</p>

<p><em>If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help.</em></p><p><strong>Selective Serotonin Reuptake Inhibitor (SSRI)</strong> works on <em>serotonin</em>, an essential neurotransmitter (chemical messenger used to communicate between brain cells), that plays a role in feelings of pleasure and comfort, as well as thinking, memory, sleep, digestion, and circulation. SSRIs can decrease the physiological symptoms of GAD, such as muscle tension, difficulties with sleep, and headaches.</p>

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<p><strong>Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)</strong> block the reabsorption (reuptake) of the neurotransmitters <em>serotonin </em>and <em>norepinephrine </em>in the brain.</p>

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<h4 style="color:#5ba2b6;"><strong>2. Buspirone</strong></h4>

<p><strong>Buspirone </strong>is an anti-anxiety medication that belongs to the drug class known as azapirones and is used as a <em>second-line </em>treatment option for GAD. This medication is slow-acting and <strong><em>does not provide immediate relief; takes 2-4 weeks</em></strong> to work when taken on a scheduled basis. Buspirone is most commonly used in combination with an SSRI or an SNRI to enhance the effect of the antidepressant. <a href="https://www.marleydrug.com/checkout/Buspirone" rel="noopener noreferrer" target="_blank">Buy Buspirone now</a></p>

<p style="margin-bottom:5px;">Common side effects of buspirone include:</p>

<ul>
<li style="margin-bottom:5px;">Nausea</li>
<li style="margin-bottom:5px;">Dizziness and/or drowsiness</li>
<li style="margin-bottom:5px;">Headache</li>
<li style="margin-bottom:5px;">Lightheadedness</li>
</ul>

<h4 style="color:#5ba2b6;"><strong>3. Benzodiazepines</strong></h4>

<p><strong>Benzodiazepines</strong> are sedatives that enhance the effect of the neurotransmitter <em>GABA</em>, which is the primary inhibitory (“turn off”) signaler in the brain. GABA plays a role in feeling calm, muscle relaxation, decreasing insomnia, and a decrease in brain activity. These medications are used to <em>relieve acute symptoms </em>of GAD, such as the feeling of worry, muscle aches, headaches, insomnia, and restlessness.</p>

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<p>—Fast relief: Benzodiazepines do <strong>not</strong> treat the underlying cause of GAD. Unlike antidepressants, benzodiazepines work fast, causing you to experience immediate anxiety relief. This temporary anxiety relief helps you complete important obligations that you may have been putting off, such as traveling, giving a presentation, or interviewing for a job.</p>

<p>—Short-term use: Benzodiazepines can be appropriate for short-term use when there is a sudden onset of anxiety, causing increased stress, insomnia, and disruption of life. This can be due to a recent death of a loved one, a natural disaster, or another stressful situation.</p>

<p style="margin-bottom:5px;">Common side effects of benzodiazepines include:</p>

<ul>
<li style="margin-bottom:5px;">Impaired coordination</li>
<li style="margin-bottom:5px;">Drowsiness</li>
<li style="margin-bottom:5px;">Confusion</li>
<li style="margin-bottom:5px;">Dizziness</li>
<li style="margin-bottom:5px;">Depression</li>
<li style="margin-bottom:5px;">Vision problems</li>
</ul>

<h5><strong>Safe Use of Benzodiazepines</strong></h5>

<p>Benzodiazepines should <strong>not be used for more than 1–2 weeks</strong>, as this can <em>increase the risk for physical dependence (addiction)</em>. Mixing these medications with alcohol can be very dangerous.</p>

<div style="background-color:#5ba2b6; color:#ffffff; margin: 30px auto; padding:25px 5% 10px 5%; ">
<h2><strong>When To See a Doctor</strong></h2>

<p style="margin-bottom:5px;">Some occasional nerves are normal, but seek medical help if you:</p>

<ul>
<li style="margin-bottom:5px;">Feel like you’re worrying too much and it’s starting to affect your quality of life.</li>
<li style="margin-bottom:5px;">Feel depressed, agitated, or have other mental health concerns along with anxiety.</li>
<li style="margin-bottom:5px;">Have suicidal thoughts or behaviors—Seek immediate emergency treatment.</li>
</ul>

<h2><strong>Where Can I Find Medications to Treat GAD?</strong></h2>

<p>Many people struggling with GAD have suffered from symptoms for a long time before seeking help. If you have any symptoms of GAD, talk to your healthcare provider and send your prescription to Marley Drug. Save up to 95% compared to your local pharmacy by using Marley Drug.</p>

<a class="btn btn-center btn-brand" href="https://www.marleydrug.com/antidepressants" target="_blank" style="color:#222222; font-weight:600; text-deocration:none;">Antidepressant list for $70/year</a>
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</div>

Feeling anxious, nervous, or agitated? You’re not alone! General Anxiety Disorder (GAD) affects 6.8 million adults every year. Although GAD is among the most common mental illnesses in the United States, it can significantly affect your quality of life.

Learn about signs and symptoms of general anxiety disorder (GAD) along with how it is diagnosed, causes, and treatment options available.

Medication Treatment for General Anxiety Disorder (GAD)

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Provide us your prescription details

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