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<h2><strong>What is Sertraline </strong>(Zoloft)?</h2><p>Sertraline is an antidepressant medication called a “selective serotonin reuptake inhibitor” (SSRI). Even though serotonin is termed an antidepressant, it’s indicated to treat more conditions than just depression.</p><p>The mental health conditions that sertraline has been approved by the FDA to treat include:</p><ul><li>Major depressive disorder (MDD) </li><li>Obsessive-compulsive disorder (OCD) </li><li>Panic disorder (PD) </li><li>Post-traumatic stress disorder (PTSD) </li><li>Social anxiety disorder (SAD) </li><li>Premenstrual dysphoric disorder (PMDD) </li></ul>


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<h2><strong>Common Questions about Sertraline</strong></h2>

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<h2><strong>Sertraline is on Marley Drug’s Wholesale Price List</strong></h2><p style="font-weight:300; line-height:1.6;">Our Wholesale Price List offers affordable pricing on many commonly prescribed generics. You can get Sertraline either in a 12-month supply for $70 or a 6-month supply for $37.</p><p><a href="https://www.marleydrug.com/wholesale-price-list-medications" rel="noopener noreferrer" target="_blank">Check our&nbsp;full list</a> <br><br><br></p>

<p class="ql-align-center">Through our online portal you can provide us your medical history and prescription details. Questions? Call <a href="tel:1-800-810-7790" rel="noopener noreferrer">800-810-7790</a>.</p>

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<h2>Have medication questions?<br>Talk with a pharmacist today.</h4>
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<h2><strong>How does Sertraline work?</strong></h2><p>Sertraline is part of a class of medications called <strong>selective serotonin reuptake inhibitors (SSRIs)</strong>. These medications help to <strong>increase the amount of 'serotonin' in your brain<span class="ql-cursor">﻿</span></strong>. Serotonin is a chemical in your brain that increases happiness, stabilizes ones mood, and decreases obsessive and anxious thoughts.</p><p>SSRIs work to increase serotonin in the brain by blocking your brains ability to reuptake serotonin. This allows serotonin to stay around longer and send out more mood-stabilizing signals. </p>

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<p>Depression is classified as a mood disorder that may be described as feelings of loss, anger or sadness that interfere with one’s everyday activities. An estimated 1 in 15 adults (6.7%) experience depression in a given year. </p>

<p>On average, depression first appears during the late teens to mid-20s, although it can occur at any time. It has been shown that <strong>one-third of women will experience a major depressive episode at least once in their lifetime</strong>. There is also a high degree of heritability (approximately 40%) when immediate relatives such as parents or siblings have depression. </p>

<p style="padding:10px; border:2px dotted #efefef; background-color:#F1F4F4; text-align:center;">See our blog on <a href="https://www.marleydrug.com/blog/general-anxiety-disorder-medication" rel="noopener noreferrer" target="_blank">General Anxiety Disorder (GAD)</a></p>

<h3><strong>Signs and symptoms</strong></h3>

<p>Depression can appear in many different forms and usually depends on each individual person. They can vary in how often they appear, the severity of the symptoms, as well as how long these feelings last for. If you have experienced some of the following signs and symptoms nearly everyday for at least 2 weeks, you may be living with depression:</p>

<ul>
<li style="margin-bottom:5px;">Feeling sad or “empty”</li>
<li style="margin-bottom:5px;">Feeling bothered, annoyed or angry</li>
<li style="margin-bottom:5px;">A loss of interest in hobbies you once enjoyed</li>
<li style="margin-bottom:5px;">Decreased energy levels</li>
<li style="margin-bottom:5px;">Difficulty sleeping</li>
<li style="margin-bottom:5px;">Thoughts of death, suicide or self-harm </li>
</ul>

<br>
<img src="https://marley-storage.imgix.net/c8f19f90-7ddc-4c88-bfa8-457e0da84836/BL-depression-symptoms.png" alt="Depression Symptoms">
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<h3><strong>Depression risk factors</strong></h3>

<p>There are many factors that can affect one’s risk of developing depression. These can be biochemical, medical, social, genetic or circumstantial in nature. Some common risk factors include:</p>

<ul style="list-style-type:none; padding-left:0;">
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Sex:</span> Females are at higher risk of developing depression than men.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Genetics:</span> You have a higher risk of developing depression if a family member has also had depression. </li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Socioeconomic status: </span> This includes financial problems and perceived low social status.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Certain medications:</span> These may include hormonal birth control, <a href="https://www.marleydrug.com/blog/corticosteroid">corticosteroids</a> and <a href="https://www.marleydrug.com/blog/what-are-beta-blockers">beta-blockers</a>.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Vitamin D deficiency:</span>Low levels of vitamin D have been linked to depressive symptoms.</li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Gender identity:</span> Transgender people have a risk of depression nearly 4-fold higher than cisgender people. </li>
<li style="margin-bottom:10px;"><span style="font-weight:600; color:#4b94a9; font-size:1em;">Medical illness:</span> People with <a href="https://www.marleydrug.com/heart-disease">heart disease</a> are twice as likely to develop depression than people who don’t, and 1 in 4 people with cancer may experience depression. </li>
</ul>

<h3><strong><a href="https://www.marleydrug.com/blog/different-types-of-depression">Depression types</a></strong></h3>

<p>There are 2 major types of depression that differ by symptom severity and persistence. </p>

<p><span style="font-weight:600; color:#4b94a9;">Major depressive disorder (MDD):</span> This is the more severe form of depression and is characterized by persistent feelings of sadness, hopelessness and worthlessness that will not go away on their own. In order to diagnose someone with clinical depression they must experience 5 or more of the following symptoms over a 2-week period:</p>

<ul>
<li style="margin-bottom:5px;">Feeling depressed most of the day</li>
<li style="margin-bottom:5px;">Significant weight loss or gain</li>
<li style="margin-bottom:5px;">Loss of interest in most regular activities</li>
<li style="margin-bottom:5px;">Excessive sleeping or inability to sleep</li>
<li style="margin-bottom:5px;">Slowed thinking or movement</li>
<li style="margin-bottom:5px;">Fatigue most days</li>
<li style="margin-bottom:5px;">Feelings of worthlessness or guilt</li>
<li style="margin-bottom:5px;">Loss of concentration or indecisiveness </li>
<li style="margin-bottom:5px;">Recurring thoughts of death or suicide </li>

</ul>

<p><span style="font-weight:600; color:#4b94a9;">Persistent depressive disorder (PDD):</span> This is a milder form of depression but it is more chronic. In order to be diagnosed with this disorder your symptoms must be present for at least 2 years. Since these symptoms last longer than MDD, it can have a larger impact on your life. It is very common for people with PDD to lose interest in normal daily activities, feel hopeless, have low self-esteem and lack productivity. </p>

<p><span style="font-weight:600; color:#4b94a9;">Postpartum depression:</span> This is in a category of its own and usually refers to depression after childbirth. Postpartum depression affects 1 in 9 new parents. Surprising to most, <strong>this can affect both men and women</strong>. The symptoms usually appear 3-6 months after birth and if they last longer than 2 weeks you may be experiencing postpartum depression. Including the symptoms already listed previously you may also experience:</p>

<ul>
<li style="margin-bottom:5px;">Having thoughts of hurting the baby or yourself</li>
<li style="margin-bottom:5px;">Not having an interest in the baby as if your baby is someone else’s</li>
<li style="margin-bottom:5px;">Having memory problems</li>
<li style="margin-bottom:5px;">Withdrawing from friends and family</li>
</ul>

<h3><strong>Depression medication</strong></h3>

<p>Along with other treatments such as psychotherapy (talking to a therapist), medications are often prescribed to help alleviate some of the symptoms associated with depression. These include:</p>

<p><span style="font-weight:600; color:#4b94a9;">Selective serotonin reuptake inhibitors (SSRIs):</span> These are the most commonly prescribed <a href="https://www.marleydrug.com/blog/ssri-and-snri">antidepressants</a> because they tend to have fewer side effects. They treat depression by increasing the availability of the neurotransmitter's serotonin (happiness chemical). SSRIs include <a href="https://www.marleydrug.com/checkout/Citalopram"  target="_blank" style="color:#222222;">citalopram</a> (Celexa), <a href="https://www.marleydrug.com/checkout/Escitalopram" target="_blank" style="color:#222222;">escitalopram</a> (Lexapro), <a href="https://www.marleydrug.com/checkout/Fluoxetine"  target="_blank" style="color:#222222;">fluoxetine</a> (Prozac), <a href="https://www.marleydrug.com/checkout/Paroxetine" target="_blank" style="color:#222222;">paroxetine</a> (Paxil) and <a href="https://www.marleydrug.com/checkout/sertraline" target="_blank" style="color:#222222;">sertraline</a> (Zoloft). </p>

<p><span style="font-weight:600; color:#4b94a9;">Serotonin-norepinephrine reuptake inhibitors (SNRIs):</span> These treat depression by increasing the amount of the neurotransmitter’s serotonin and norepinephrine in your brain. SNRIs include <a href="https://www.marleydrug.com/checkout/Duloxetine" target="_blank" style="color:#222222;">duloxetine</a> (Cymbalta), <a href="https://www.marleydrug.com/checkout/khedezla~" target="_blank" style="color:#222222;">desvenlafaxine</a> (Khedezla) and <a href="https://www.marleydrug.com/checkout/Venlafaxine" target="_blank" style="color:#222222;">venlafaxine</a> (Effexor XR). </p>

<p><span style="font-weight:600; color:#4b94a9;">Tricyclic and tetracyclic antidepressants:</span> Both of these treat depression by increasing the amount of the neurotransmitter’s serotonin and norepinephrine in the brain. These can be very effective but tend to cause more severe side effects, so they are generally not prescribed unless you’ve tried an SSRI first. Medications in this category include <a href="https://www.marleydrug.com/checkout/Amitriptyline" target="_blank" style="color:#222222;">amitriptyline</a> (Amitid), <a href="https://www.marleydrug.com/checkout/Mirtazapine" target="_blank" style="color:#222222;">mirtazapine</a> (Remeron) and <a href="https://www.marleydrug.com/checkout/Nortriptyline"  target="_blank" style="color:#222222;">nortriptyline</a> (Pamelor). </p>

<p><span style="font-weight:600; color:#4b94a9;">Atypical antidepressant:</span> These medications don’t fit into any of the other categories of antidepressants but they treat depression in a similar manner. These include <a href="https://www.marleydrug.com/checkout/Bupropion" target="_blank" style="color:#222222;">bupropion</a> (Wellbutrin) and <a href="https://www.marleydrug.com/checkout/Trazodone"  target="_blank" style="color:#222222;">trazodone</a> (Desyrel). </p>

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<h3><strong>When to see a doctor</strong></h3>

<p>Depression is a highly stigmatized disease that a lot of people do not seek treatment for, in fact, 1 in 6 people (16.6%) will experience it in their lifetime. Depression has a variety of symptoms that affect each individual differently.</p>

<p>If you feel depressed, or think you feel depressed, make an appointment with your healthcare provider as soon as you can. Talking about it is the first step to getting your mental health back on track. </p>

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<div style="font-size:0.85em;">
<p><strong><h6>Data in this article was informed by:</strong><br>(1) Mayo Clinic (2) Healthline (3) Psychiatry.org</p>
</div>

<hr style="border-bottom: dotted 1px #efefef;">

Depression can appear in many different forms and usually depends on each individual person. They can vary in how often they appear, the severity of the symptoms, as well as how long these feelings last for. If you have experienced some of the following signs and symptoms nearly everyday for at least 2 weeks, you may be living with depression.

1 in 15 adults experience depression a year. Learn about depression symptoms, risk factors, treatment options, and when to seek help from a medical professional.

What Is Depression | Symptoms, Risks & Treatment Options

Mental Health

What Depression Is

<p style="font-size:1.35em; margin: 30px auto 30px auto; padding-left:15px; border-left:5px solid #fee203;"><em>Feeling anxious, nervous, or agitated? You’re not alone! General Anxiety Disorder (GAD) affects 6.8 million adults every year. Although GAD is among the most common mental illnesses in the United States, it can significantly affect your quality of life.</em></p>

<h2><strong>What is General Anxiety Disorder (GAD)?</strong></h2>

<p>Normally, individuals occasionally experience fear and worry when faced with situations at work, school, or home, such as taking an exam, speaking in public, or going for a job interview. You may even experience physical symptoms, such as increased heart rate, shortness of breath, upset stomach, insomnia, or fatigue. These symptoms of occasional anxiety come and go, tend to resolve once the temporary issue is over, and do not interfere with your daily life.</p>

<p>An <a href="https://www.marleydrug.com/blog/three-major-forms-of-anxiety">anxiety disorder</a> is different. When individuals have an anxiety disorder, they experience persistent or excessive symptoms that interfere with their ability to do well at school or work and can harm relationships. People with a generalized anxiety disorder (GAD) feel anxious and worried most of the time, and these worries may be chronic (long-term), severe, and can cause great distress.</p>

<p style="padding:10px; border:2px dotted #efefef; background-color:#F1F4F4; text-align:center;">See also our blog on <a href="https://www.marleydrug.com/blog/what-depression-is" rel="noopener noreferrer" target="_blank">What is Depression</a>.</p>

<h2><strong>Signs and Symptoms of GAD:</strong></h2>

<p >GAD is a type of anxiety disorder characterized by long-term anxiety, excessive worry, tension, and dread, even when nothing has occurred to trigger or provoke it.</p>

<p style="margin-bottom:5px;">GAD is marked by physiological and physical symptoms that persist for over 6 months and include:</p>

<ul>
<li style="margin-bottom:5px;">Rapid heartbeat (palpitations)</li>
<li style="margin-bottom:5px;">Feeling restless, or “on-edge”</li>
<li style="margin-bottom:5px;">Feeling shaky or weak</li>
<li style="margin-bottom:5px;">Easily tired and fatigued</li>
<li style="margin-bottom:5px;">Feeling irritable</li>
<li style="margin-bottom:5px;">Having difficulty concentrating</li>
<li style="margin-bottom:5px;">Difficulty controlling feelings of worry</li>
<li style="margin-bottom:5px;">Problems relaxing</li>
<li style="margin-bottom:5px;">Being easily startled</li>
<li style="margin-bottom:5px;">Having difficulty falling or staying asleep</li>
<li style="margin-bottom:5px;">Increased muscle aches, tension, and/or soreness (i.e. sore jaw or back)</li>
<li style="margin-bottom:5px;">Experiencing difficulty participating in everyday activities (i.e. work, study, seeing friends and family)</li>
<li style="margin-bottom:5px;">Headaches and/or light-headedness</li>
<li style="margin-bottom:5px;">Sweaty palms</li>
<li style="margin-bottom:5px;">Dry mouth</li>
<li style="margin-bottom:5px;">Trouble breathing</li>
</ul>

<h2><strong>How is GAD Diagnosed?</strong></h2>

<p>Symptoms must be present most days of the week for at least 6 months in order to receive a diagnosis of GAD. GAD is diagnosed with a mental health screening completed by your doctor or mental health professional. You may answer self-report questionnaires regarding your symptoms and how long you’ve had them, such as the <u>Generalized Anxiety Disorder Scale-7</u>, which will help your doctor identify the precise diagnosis and <em>severity </em>of GAD. Diagnosis may also include:</p>

<ul>
<li style="margin-bottom:5px;">Bloodwork and/or urine test, to examine hormone levels that may signify a thyroid disorder.</li>
<li style="margin-bottom:5px;">A gastric reflux test, for instance, an X-ray of your digestive system or an endoscopy procedure to examine your esophagus for <a href="https://www.marleydrug.com/managing-stomach-acid">GERD</a>.</li>
<li style="margin-bottom:5px;">Stress test, to check for heart conditions.</li>
<li style="margin-bottom:5px;">Physical exam, to check for signs indicating that your anxiety may be related to medications or an underlying medical condition.</li>
<li style="margin-bottom:5px;">Patient interview and/or psychological questionnaire to form medical history, symptom details, and determine a diagnosis.</li>
<li style="margin-bottom:5px;">An assessment of symptom criteria, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).</li>
</ul>

<h2><strong>What Causes GAD?</strong></h2>

<p>In many cases, a combination of factors can contribute to the development of GAD.</p>

<ol>
<li style="margin-bottom:20px;"><strong>Biological factors</strong>: Differences in brain chemistry and function.</li>

<li style="margin-bottom:20px;"><strong>Psychological factors</strong>: Particular personality traits can increase your risk of GAD. For example, being emotional or a distressed person, sensitive/fragile, having difficulty enduring irritation/annoyance, and having a personality that strives for flawlessness. Additionally, those that are more negative, have a timid character or tend to evade danger.</li>

<li style="margin-bottom:20px;"><strong>Family history</strong>: Genetics play a role in GAD when individuals have a history of mental health problems in their family.</li>

<li style="margin-bottom:20px;"><strong>Health conditions</strong>: Thyroid issues or heart arrhythmias.</li>

<li style="margin-bottom:20px;"><strong>Traumatic events</strong>: You may have an increased risk of developing GAD if you have experienced a severe life change that has caused nervousness, including grief, childbirth, or workplace-induced trauma. If you have experienced any form of abuse, such as emotional, physical, or sexual abuse, you may be more at risk of developing GAD.</li>
</ol>

<p><img src="https://marley-storage.imgix.net/43d47025-408c-4156-b275-b69f95f7b8f5/BL-anxiety-symptoms.png"></p>

<h1><strong>Treatment Options for GAD</strong></h1>

<p>Treatment options are dependent on how much GAD is affecting your ability to function in your daily life. Various types of medications are used to treat GAD.</p>

<h4 style="color:#5ba2b6;"><strong>1. Antidepressants</strong></h4>

<p>Antidepressants are used as <em>first-line </em>medication options to treat GAD and relieve symptoms. These medications need to be titrated (built-up) in your system slowly to minimize anxiousness. SSRIs and SNRIs are used daily and <strong><em>do not provide immediate relief; takes at least 4 weeks or more </em></strong> for a noticeable effect.</p>

<p>When first starting <a href="https://www.marleydrug.com/blog/ssri-and-snri">SSRIs/SNRIs</a>, you may experience some unpleasant side effects, however, they generally decrease or go away after 4-8 weeks.</p>

<p style="margin-bottom:5px;">Common side effects include:</p>

<ul>
<li style="margin-bottom:5px;">Decreased libido (sexual arousal)</li>
<li style="margin-bottom:5px;">Drowsiness</li>
<li style="margin-bottom:5px;">Insomnia</li>
<li style="margin-bottom:5px;">Nausea—Taking your medication with food may reduce nausea</li>
<li style="margin-bottom:5px;">Diarrhea</li>
<li style="margin-bottom:5px;">Dry mouth</li>
<li style="margin-bottom:5px;">Headache</li>
<li style="margin-bottom:5px;">Dizziness</li>
</ul>

<h5><strong>Suicide Risk and Antidepressants:</strong></h5>

<p>Although most antidepressants are generally safe, the FDA requires that <strong>all </strong>antidepressants carry a <strong>black box warning </strong>(the strictest warnings for prescriptions) of a possible <strong>increase in suicidal thoughts or actions </strong>in some children, teenagers, or young adults under 25 within the first few months of treatment or when the dose is changed.</p>

<p><em>If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help.</em></p><p><strong>Selective Serotonin Reuptake Inhibitor (SSRI)</strong> works on <em>serotonin</em>, an essential neurotransmitter (chemical messenger used to communicate between brain cells), that plays a role in feelings of pleasure and comfort, as well as thinking, memory, sleep, digestion, and circulation. SSRIs can decrease the physiological symptoms of GAD, such as muscle tension, difficulties with sleep, and headaches.</p>

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<p><strong>Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)</strong> block the reabsorption (reuptake) of the neurotransmitters <em>serotonin </em>and <em>norepinephrine </em>in the brain.</p>

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<h4 style="color:#5ba2b6;"><strong>2. Buspirone</strong></h4>

<p><strong>Buspirone </strong>is an anti-anxiety medication that belongs to the drug class known as azapirones and is used as a <em>second-line </em>treatment option for GAD. This medication is slow-acting and <strong><em>does not provide immediate relief; takes 2-4 weeks</em></strong> to work when taken on a scheduled basis. Buspirone is most commonly used in combination with an SSRI or an SNRI to enhance the effect of the antidepressant. <a href="https://www.marleydrug.com/checkout/Buspirone" rel="noopener noreferrer" target="_blank">Buy Buspirone now</a></p>

<p style="margin-bottom:5px;">Common side effects of buspirone include:</p>

<ul>
<li style="margin-bottom:5px;">Nausea</li>
<li style="margin-bottom:5px;">Dizziness and/or drowsiness</li>
<li style="margin-bottom:5px;">Headache</li>
<li style="margin-bottom:5px;">Lightheadedness</li>
</ul>

<h4 style="color:#5ba2b6;"><strong>3. Benzodiazepines</strong></h4>

<p><strong>Benzodiazepines</strong> are sedatives that enhance the effect of the neurotransmitter <em>GABA</em>, which is the primary inhibitory (“turn off”) signaler in the brain. GABA plays a role in feeling calm, muscle relaxation, decreasing insomnia, and a decrease in brain activity. These medications are used to <em>relieve acute symptoms </em>of GAD, such as the feeling of worry, muscle aches, headaches, insomnia, and restlessness.</p>

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<p>—Fast relief: Benzodiazepines do <strong>not</strong> treat the underlying cause of GAD. Unlike antidepressants, benzodiazepines work fast, causing you to experience immediate anxiety relief. This temporary anxiety relief helps you complete important obligations that you may have been putting off, such as traveling, giving a presentation, or interviewing for a job.</p>

<p>—Short-term use: Benzodiazepines can be appropriate for short-term use when there is a sudden onset of anxiety, causing increased stress, insomnia, and disruption of life. This can be due to a recent death of a loved one, a natural disaster, or another stressful situation.</p>

<p style="margin-bottom:5px;">Common side effects of benzodiazepines include:</p>

<ul>
<li style="margin-bottom:5px;">Impaired coordination</li>
<li style="margin-bottom:5px;">Drowsiness</li>
<li style="margin-bottom:5px;">Confusion</li>
<li style="margin-bottom:5px;">Dizziness</li>
<li style="margin-bottom:5px;">Depression</li>
<li style="margin-bottom:5px;">Vision problems</li>
</ul>

<h5><strong>Safe Use of Benzodiazepines</strong></h5>

<p>Benzodiazepines should <strong>not be used for more than 1–2 weeks</strong>, as this can <em>increase the risk for physical dependence (addiction)</em>. Mixing these medications with alcohol can be very dangerous.</p>

<div style="background-color:#5ba2b6; color:#ffffff; margin: 30px auto; padding:25px 5% 10px 5%; ">
<h2><strong>When To See a Doctor</strong></h2>

<p style="margin-bottom:5px;">Some occasional nerves are normal, but seek medical help if you:</p>

<ul>
<li style="margin-bottom:5px;">Feel like you’re worrying too much and it’s starting to affect your quality of life.</li>
<li style="margin-bottom:5px;">Feel depressed, agitated, or have other mental health concerns along with anxiety.</li>
<li style="margin-bottom:5px;">Have suicidal thoughts or behaviors—Seek immediate emergency treatment.</li>
</ul>

<h2><strong>Where Can I Find Medications to Treat GAD?</strong></h2>

<p>Many people struggling with GAD have suffered from symptoms for a long time before seeking help. If you have any symptoms of GAD, talk to your healthcare provider and send your prescription to Marley Drug. Save up to 95% compared to your local pharmacy by using Marley Drug.</p>

<a class="btn btn-center btn-brand" href="https://www.marleydrug.com/antidepressants" target="_blank" style="color:#222222; font-weight:600; text-deocration:none;">Antidepressant list for $70/year</a>
<br><br>
<a class="btn btn-center btn-brand" href="https://www.marleydrug.com/desvenlafaxine" target="_blank" style="color:#222222; font-weight:600; text-deocration:none;">Desvenlafaxine for $20.88/month</a>
<br><br>

</div>

Feeling anxious, nervous, or agitated? You’re not alone! General Anxiety Disorder (GAD) affects 6.8 million adults every year. Although GAD is among the most common mental illnesses in the United States, it can significantly affect your quality of life.

Learn about signs and symptoms of general anxiety disorder (GAD) along with how it is diagnosed, causes, and treatment options available.

Medication Treatment for General Anxiety Disorder (GAD)

<h2 style="color:#5ba2b6; font-weight:600;">1. Sertraline Works to Increase The Effect of Serotonin in Your Brain</h2>

<p>Sertraline is an <a href="https://www.marleydrug.com/blog/ssri-and-snri">antidepressant</a> medication called a “selective serotonin reuptake inhibitor” (SSRI). <strong>These medications work to increase the amount of a chemical called “serotonin” in your brain.</strong> Serotonin is a chemical that works in your brain to increase your happiness, decrease obsessive and anxious thoughts, and stabilize your mood. Serotonin gets released by one nerve cell and then goes and sends signals to another nerve cell to regulate mood. Once the serotonin has acted on the receiving cell, it then gets re-taken up by the cell that sent it out so that there isn’t too much signal being sent. </p>

<p><strong>SSRIs work by stopping this reuptake of serotonin from the signal-sending nerve cell.</strong> This then allows the serotonin to stay around for longer and be able to send out more mood-stabilizing signals. This has very positive effects for many mental health conditions, in which serotonin is thought to be at decreased levels. </p>


<h2 style="color:#5ba2b6; font-weight:600;">2. Sertraline Is Approved to Treat 6 Mental Health Conditions</h2>

<p>Even though sertraline is termed an antidepressant, it’s indicated to treat more conditions than just depression. 
<a href="https://www.marleydrug.com/blog/what-depression-is">Depression</a> has been thought to be exacerbated by a decrease in serotonin levels, so increasing the amount available to send signals has very positive effects on depression. Most of the other mental health conditions that sertraline has been approved to treat are <a href="https://www.marleydrug.com/anxiety">anxiety</a>-based. Sertraline is helpful for these conditions because serotonin also works to decrease the overactive thoughts associated with OCD and social anxiety disorder. </p>

<p style="margin-bottom:10px;">The mental health conditions that sertraline has been approved by the FDA to treat include:</p>

<ul>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Major depressive disorder</span> (MDD) </li>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;"><a href="https://www.marleydrug.com/blog/treating-ocd-with-medication">Obsessive-compulsive disorder</a></span> (OCD) </li>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Panic disorder</span> (PD) </li>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;"><a href="https://www.marleydrug.com/blog/ptsd">Post-traumatic stress disorder</a>
</span> (PTSD) </li>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Social anxiety disorder</span> (SAD) </li>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Premenstrual dysphoric disorder</span> (PMDD</li>
</ul>

<h2 style="color:#5ba2b6; font-weight:600;">3. 7 Common Side Effects</h2>

<p>As with most medications, there is always a risk of experiencing side effects while taking sertraline. Many people experience side effects of sertraline within the first 2-4 weeks of starting this medication. These side effects will change and should decrease after about 4 weeks of taking sertraline. </p>

<p style="background-color:#EDF2F4; border: 2px dotted #8DA3A8; text-align:center;">Learn more about the <a href="https://www.marleydrug.com/blog/what-to-expect-during-the-first-few-weeks-on-antidepressants" target="_blank">first few weeks of taking antidepressants</a>. </p>

<p style="margin-bottom:10px;">However, sometimes certain people continue to experience reactions even after the initial time period. These effects are usually mild, and should not interfere with your day-to-day life. The 7 most common side effects of sertraline include:</p>

<ul>
       <li style="margin-bottom:7px;">Diarrhea</li>
       <li style="margin-bottom:7px;">Nausea</li>
       <li style="margin-bottom:7px;">Dry mouth</li>
       <li style="margin-bottom:7px;">Increased sweating</li>
       <li style="margin-bottom:7px;">Difficulty sleeping</li>
       <li style="margin-bottom:7px;">Dizziness</li>
       <li style="margin-bottom:7px;"><strong>Emotional changes including increased thoughts of self-harm and suicide*</strong></li>
</ul>

<p>If you experience side effects in the first 2-4 weeks and/or following this time period make sure to discuss it with your healthcare provider, so they can determine if this medication is still right for you. </p>

<h6 style="margin-top:0;"><strong>*If you experience increased thoughts of self-harm and/or suicide, seek medical attention immediately.</strong></h6>

<h2 style="color:#5ba2b6; font-weight:600;">4. Medications To Avoid While Taking Sertraline</h2>

<p style="margin-bottom:15px;">There are two medications that are explicitly contradicted with use at the same time as sertraline. These medications are:</p>
<ul>
       <li><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Monoamine oxidase inhibitors (MAOIs)</span><br>
         Very serious, and even fatal, reactions have been reported when any MAOI is used in combination with sertraline. </li>
       
       <li><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Pimozide</span><br>
       The combination of sertraline and pimozide can lead to heartbeat irregularities</li>
</ul>

<p>There is a very long list of other medications that should likely not be taken at the same time as sertraline. Because this list is so long, it is very important to ensure your healthcare provider is aware of all prescription medications, over the counter medications, supplements, and natural health products you are taking. </p>

<p>For example, <strong>any medication that increases serotonin in your body should be avoided while taking sertraline</strong>. As sertraline also increases serotonin, additional serotonin-increasing medications may increase your serotonin too much. When serotonin gets too high in the body, it can lead to something called “serotonin syndrome”, which shows up as diarrhea, shakiness, agitation, and eventually an irregular heart rate and possibly <a href="https://www.marleydrug.com/blog/types-of-seizures">seizures</a>. </p>

<p style="margin-bottom:10px;">Examples of the medications that should be avoided due to the possibility of serotonin syndrome include:</p>

<ul>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Other antidepressants</span> (SNRIs, TCAs)</li>
       <li style="margin-bottom:10px;"><span style="border-bottom:.125em #fee203 solid; font-weight:600;">Triptans</span> (rizatriptan, sumatriptan)</li>
</ul>      

<h2 style="color:#5ba2b6; font-weight:600;">5. Sertraline is One of the Safer SSRIs for Pregnant and Breastfeeding Women</h2>

<p>Overall, <strong>it is thought that sertraline is relatively safe for people to take while pregnant</strong>. Animal studies have not shown sertraline to be overly dangerous to either the mother or the fetus. This being said, there have not been extensive studies done in humans due to the possible safety risks to the pregnant mother and the fetus. The benefit of taking sertraline to improve mental health must therefore be weighed with your healthcare provider against the slight possibility of risk to the fetus. </p>

<p>Sertraline has been shown to appear in breastmilk. It is thought that the levels of sertraline are quite low in comparison to other SSRIs, so this may be a good antidepressant option for women who are nursing. Regardless, <strong>it is always a conversation to have with your healthcare provider to determine if there is more benefit to you to continue taking your medication or if the risk of the baby getting medication through the breastmilk is too high</strong>.   </p>




<h2 style="color:#5ba2b6; font-weight:600;">You Can Get Sertraline For As Low As $6 Per Month at Marley Drug!</h2>

<p>Sertraline is a medication that’s most often taken for an extended period of time. Because of this, it’s most convenient to get a longer supply of the medication at each time. At a typical pharmacy, a 6-month supply of generic sertraline would cost anywhere from $134 to $417. </p>

<p>However, <strong>at Marley Drug, you can get a 6-month supply of sertraline for $37 or a 12-month supply for $70</strong>. This low price is possible because we get our medications directly from accredited wholesalers, rather than from insurance companies. Insurance companies usually hike up the costs of medications with arbitrary service fees, so cutting out this step allows us to keep our medication costs low. </p>

<p>To learn more about how you can get your sertraline prescription from Marley Drug, just call us at <a href="tel:18008107790">1-800-810-7790</a> </p>

<h6>Prices mentioned in this article are based on average retail price at major box chain pharmacy in the U.S. as of August 2, 2022.</h6>

<br><br>

<div style="font-size:.9em; line-height:1.4; padding:25px 0; border-bottom:2px dotted #ededed; border-top:2px dotted #ededed;"> 

<strong>References:</strong> 

<ol> 

       <li style="margin-bottom:10px;" >Zoloft (sertraline) – Access data FDA-Approved Drugs [Internet]. Amended 12/2016; accessed 08/2022].</li> 

       <li style="margin-bottom:10px;" >Zoloft: generic sertraline – GoodRx (https://www.goodrx.com). Accessed 2022-08-02</li> 

</ol> 

</div>

Sertraline is termed an antidepressant, however, it’s indicated to treat more conditions than just depression. Depression has been thought to be exacerbated by a decrease in serotonin levels, so increasing the amount available to send signals has very positive effects on depression. Most of the other mental health conditions that sertraline has been approved to treat are anxiety-based. Sertraline is helpful for these conditions because serotonin also works to decrease the overactive thoughts associated with OCD and social anxiety disorder.

Learn about sertraline: how it works, conditions it treats, side effects and interactions with other drugs.

6 Things You Should Know About Sertraline

Helpful Articles on Mental Health and Sertraline

With a valid prescription, you can have Sertraline delivered to your door by Marley Drug. Provide us your prescription details and we will ship you sertraline in 2-3 business days. Just $70 for a full year supply.

Get Sertraline (generic Zoloft^®) for $70/year

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Common Questions about Sertraline

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Have medication questions?
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Common Questions about Sertraline

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What Depression Is

Medication Treatment for General Anxiety Disorder (GAD)

6 Things You Should Know About Sertraline

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What is Sertraline (Zoloft)?

Common Questions about Sertraline

Sertraline is on Marley Drug’s Wholesale Price List

How to Order Sertraline

Provide us your prescription details

We'll verify your prescription

Your medication will be shipped to your home

Have medication questions?Talk with a pharmacist today.

How does Sertraline work?

Common Questions about Sertraline

What Depression Is

Medication Treatment for General Anxiety Disorder (GAD)

6 Things You Should Know About Sertraline

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