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Zypitamag® vs Praluent®

Understanding Your Options for Cholesterol Management

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Lowering Cholesterol Shouldn’t Break the Bank (or Your Muscles)


Lowering your "bad" cholesterol (LDL-C) is the single best way to reduce your long-term risk of heart attack and stroke. But many patients find themselves stuck:


  • Common statins (like Atorvastatin) can cause muscle aches.
  • Injectable medications (like Praluent) are often too expensive or blocked by insurance.

How They Work: Zypitamag vs Praluent


Both medications are highly effective at lowering LDL-C, but they use different "machinery" inside your body to do it.

  • Zypitamag (Builder Block): A "third-generation" statin that blocks an enzyme in your liver used to make cholesterol. This means your body simply produces less cholesterol.
  • Praluent (Cleaning Crew): An injection that blocks a protein called PCSK9. PCSK9 destroys LDL receptors, your body’s “hooks” that remove excess cholesterol. By stopping PCSK9, your liver keeps more of these hooks, allowing it to grab and clear more cholesterol from your blood.

In short: Zypitamag reduces how much bad cholesterol your body makes, while Praluent enhances your body's ability to remove it.


How Well They Work


  • Zypitamag: Lowers LDL-C by up to 45%
  • Praluent: Lowers LDL-C by 50-60%

Cost


  • Praluent: $450-$530+/month
  • Zypitamag: $39/month cash price through Marley Drug

Praluent is extremely effective, but also extremely costly for many patients. For those who can’t afford PCSK9 inhibitors, Zypitamag is the practical, long‑term solution.


Zypitamag for People Who Struggle With Statins


Many of our patients come to us after quitting other statins due to side effects. Zypitamag is often called the "statin for people who can't take statins."


Key benefits of Zypitamag include:

  • Low myalgia (muscle pain) rate: Only 3.1% myalgia.
  • Low doses: Comes in 2 mg and 4 mg tablets; side effects often increase with dose, so effective lower doses can matter.
  • Minimal CoQ10 depletion: One theory for statin-related pain is the depletion of CoQ10 in muscles. Zypitamag appears to preserve more CoQ10 which may contribute to fewer side effects.
  • Minimal effect on blood sugar: A good option for people concerned about diabetes risk.
  • Fewer interactions: Processed through a less “crowded” pathway in the liver, making it safe for CBD products and grapefruit juice.

Rea more about Statin Intolerance

Learn about Zypitamag

What People are Saying about Zypitamag

This drug is a miracle for me! I have tried every statin on the market with copious amounts of muscle pain weakness, back pain overall, and aching in every joint. My family has genetic high cholesterol.

I was so frustrated with the ongoing pain and aching joints, I changed physicians and started with a brand-new primary care physician in May. Interestingly she also had high cholesterol. She told me about a new medicine that she thought may be good for me to take and did not feel that I would have the muscle aches and pains as I have from other statins. The name of the medicine is Zypitamag.

Since I have been taking Zypitamag, I have had no aches no pains and have tolerated this medicine extremely well. I would encourage anyone whose physician says that they are in need of a statin for cholesterol to try this medication.

Nurse from Houston

I will try to keep this simple. I am unable to tolerate statins, after trying 7 different ones. Finally a doctor suggested pitavastatin and I was able to tolerate it, but not afford it.

I have been buying pitavastatin from Canadian pharmacy. Due to the tariffs, the original place the meds came from has shut down temporarily. I was offered the option of buying it from Turkey for about $200 for a 90 day supply. I just couldn't believe that some place in the US didn't have this medication.

So, I was doing random searches and found Marley Drug. My insurance will cover pitavastatin, but my copay is$200 per month. Right now I see you as a Godsend. Thank you for your help.

Carol H.

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Why You May Not Have Heard of Zypitamag


If Zypitamag is so effective, why haven’t you heard of it?

  • Guideline inertia: Many guidelines and insurers push atorvastatin as the first statin to try, then a second or third statin before considering Zypitamag (pitavastatin).
  • Insurance restrictions: Plans often require you to “fail” other statins before they will cover Zypitamag, so many people give up before they ever reach it.

Through Marley Drug, you can access Zypitamag directly, at a transparent cash price, without waiting for insurance approvals. Plus, enjoy free shipping with every order.


How to Get Zypitamag through Marley Drug


If you want to talk to your doctor about Zypitamag, you can bring the information sheet to your next appointment. Your doctor can prescribe it to Marley Drug.

Once we receive your prescription, one of our representatives will call you to confirm it.


Questions?

Call us at 800-810-7790 or email us info@marleydrug.com.