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Zypitamag® vs Repatha®

Understanding Your Options for Heart Health

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Lowering Cholesterol Shouldn’t Break the Bank (or Your Muscles)


Lowering your "bad" cholesterol (LDL-C) is the single best way to reduce your long-term risk of heart attack and stroke. But many patients find themselves stuck:


  • Common statins (like Atorvastatin) can cause muscle aches.
  • Injectable medications (like Repatha) are often too expensive or blocked by insurance.

How They Work: Zypitamag vs Repatha


Both medications are highly effective at lowering LDL-C, but they use different "machinery" inside your body to do it.

  • Zypitamag (Builder Block): A "third-generation" statin that blocks an enzyme in your liver used to make cholesterol. Your body simply produces less of it.
  • Repatha (Cleaning Crew): An injection that blocks a protein called PCSK9. This helps your liver keep more "hooks" (receptors) to grab and clear cholesterol out of your blood.

In short: Zypitamag reduces how much bad cholesterol your body makes, while Repatha enhances your body's ability to remove it.


How Well They Work


  • Zypitamag: Lowers LDL-C by up to 45%
  • Repatha: Lowers LDL-C by 50-60%

Cost


  • Repatha: $239 – $600+/month
  • Zypitamag: $39/month cash price through Marley Drug

Repatha is extremely effective, but also extremely costly for many patients. For those who can’t afford PCSK9 inhibitors, Zypitamag is the practical, long‑term solution.


Zypitamag for People Who Struggle With Statins


Many of our patients come to us after quitting other statins due to side effects. Zypitamag is often called the "statin for people who can't take statins."


Key benefits of Zypitamag include:

  • Low myalgia (muscle pain) rate: Only 3.1% myalgia.
  • Low doses: Comes in 2 mg and 4 mg tablets; side effects often increase with dose, so effective lower doses can matter.
  • Minimal CoQ10 depletion: One theory for statin-related pain is the depletion of CoQ10 in muscles. Zypitamag appears to preserve more CoQ10 which may contribute to fewer side effects.
  • Minimal effect on blood sugar: A good option for people concerned about diabetes risk.
  • Fewer interactions: Processed through a less “crowded” pathway in the liver, making it safe for CBD products and grapefruit juice.

Rea more about Statin Intolerance

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What People are Saying about Zypitamag

Zypitamag is a fundamentally different statin. The majority of statin-intolerant patients will tolerate ZYPITAMAG.

Dr. Nate Lebowitz

I have always had trouble with statins. My doctor recommended Marley Drug’s statin, Zypitamag (pitavastatin), and I have been taking that with no side effects and my bad cholesterol has gone down significantly. It is a relief to find a statin drug that gives me no side effects.

Jacquie N.

Read more

Why You May Not Have Heard of Zypitamag


If Zypitamag is so effective, why haven’t you heard of it?

  • Guideline inertia: Many guidelines and insurers push atorvastatin as the first statin to try, then a second or third statin before considering Zypitamag (pitavastatin).
  • Insurance restrictions: Plans often require you to “fail” other statins before they will cover Zypitamag, so many people give up before they ever reach it.

Through Marley Drug, you can access Zypitamag directly, at a transparent cash price, without waiting for insurance approvals. Plus, enjoy free shipping with every order.


How to Get Zypitamag through Marley Drug


If you want to talk to your doctor about Zypitamag, you can bring the information sheet to your next appointment. Your doctor can prescribe it to Marley Drug.

Once we receive your prescription, one of our representatives will call you to confirm it.


Questions?

Call us at 800-810-7790 or email us info@marleydrug.com.